Endophenotypes in Psychopathology Research: Where Do We Stand?
Endophenotypes in Psychopathology Research: Where Do We Stand?
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DOI：
10.1146/annurev-clinpsy-050212-185540
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Rockstroh, Brigitte
中科院分区：
文献类型：
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作者：
Miller, Gregory A.;Rockstroh, Brigitte
精神病理学的内表型被认为是潜在的，未观察到的，但可测量的现象的表现，其因果关系将遗传倾向与临床障碍联系起来。几十年的研究已经导致了一些候选内表型的构建和鉴定的改进，但在寻找相关基因或内表型由遗传和环境因素驱动并反过来驱动精神病理的机制方面进展有限。目前有希望的研究途径包括发展不限于传统诊断类别的跨诊断概念，比这些类别具有更高有效性的内表型和显性精神病理学测量，以及建立病因不同贡献者之间复杂关系的建模方法。随着动物神经科学和其他基础生物和心理科学方面的研究越来越深入，有充分的理由预测，内表型概念将在精神病理学文献中变得更加重要。
Endophenotypes for psychopathology have been conceived as latent, unobserved, but measureable manifestations of phenomena that causally connect genetic liability to clinical disorder. Several decades of research have led to refinement of the construct and identification of some candidate endophenotypes, but rather limited progress on finding the genes involved or the mechanisms by which endophenotypes are driven by genetic and environmental factors and in turn drive psychopathology. Currently promising avenues for research involve development of transdiagnostic concepts not limited to traditional diagnostic categories, measures of endophenotypic and manifest psychopathology that have higher validity than those categories, and methods for modeling complex relationships among diverse contributors to etiology. With more grounding in animal neuroscience and other aspects of basic biological and psychological science, exemplified in the Research Domain Criteria initiative, there is every reason to anticipate that the endophenotype concept will grow more central in the psychopathology literature.