Glutathione-Responsive Polymeric Micelles Formed by a Biodegradable Amphiphilic Triblock Copolymer for Anticancer Drug Delivery and Controlled Release.
Glutathione-Responsive Polymeric Micelles Formed by a Biodegradable Amphiphilic Triblock Copolymer for Anticancer Drug Delivery and Controlled Release.
复制标题
DOI：
10.1021/acsbiomaterials.5b00119
复制
发表时间：
2015-06
影响因子：
5.8
通讯作者：
Zhigang Xu;Shiying Liu;Yuejun Kang;Mingfeng Wang
中科院分区：
文献类型：
--
作者：
Zhigang Xu;Shiying Liu;Yuejun Kang;Mingfeng Wang
本文介绍了一种新型的谷胱甘肽（GSH）响应性聚（乙二醇）-b-聚碳酸酯-b-聚（乙二醇）三嵌段共聚物，自组装成胶束纳米粒子和simulatrol携带疏水性抗癌药物，如多西鲁肽。这些载药胶束表现出谷胱甘肽触发的分解，导致药物释放受控和对癌细胞的细胞毒性。这种高分子药物载体系统具有合成简单、药物刺激响应性强、生物相容性好、解离片段毒性相对较低等特点，是一种具有潜在临床应用前景的抗癌药物载体。
This article presents a novel glutathione (GSH)-responsive poly(ethylene glycol)-b-polycarbonate-b-poly(ethylene glycol) triblock copolymer that self-assembles into micellar nanoparticles and simutaneously carry hydrophobic anticancer drugs such as doxirubicin. These drug-loading micelles show glutathione-triggered decomposition that leads to controlled drug release and cytotoxicity to cancer cells. This polymeric drug-carrier system integrates features of facile synthesis, stimuli-responsive drug release, good biocompatibility, and relatively low toxicity of the dissociated segments, thus representing a promising anticancer drug carrier for potential clinical applications.