CIRCADIAN-RHYTHMS OF FREQUENCY-DOMAIN MEASURES OF HEART-RATE-VARIABILITY IN HEALTHY-SUBJECTS AND PATIENTS WITH CORONARY-ARTERY DISEASE - EFFECTS OF AROUSAL AND UPRIGHT POSTURE
CIRCADIAN-RHYTHMS OF FREQUENCY-DOMAIN MEASURES OF HEART-RATE-VARIABILITY IN HEALTHY-SUBJECTS AND PATIENTS WITH CORONARY-ARTERY DISEASE - EFFECTS OF AROUSAL AND UPRIGHT POSTURE
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DOI：
10.1161/01.cir.90.1.121
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发表时间：
1994-07-01
期刊：
影响因子：
37.8
通讯作者：
AIRAKSINEN, KEJ
中科院分区：
文献类型：
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作者：
HUIKURI, HV;NIEMELA, MJ;AIRAKSINEN, KEJ
背景心血管系统神经调节的改变可能是缺血性心脏病各种表现的重要因素。本研究旨在比较无并发症冠心病（CAD）患者和年龄匹配的无心脏病证据的受试者的心脏神经调节和自主神经反应的昼夜节律。方法和结果分析20例男性患者的24小时心率变异性（HRV）频域（平均年龄52 ± 7岁），血管造影显示CAD，无心肌梗死病史，20名健康男性（平均年龄51 ± 8岁），无心脏病的临床、超声心动图或运动心电图证据。两组间心率变异性的24小时平均频域分量无显著差异。健康受试者有一个显着的昼夜节律的标准化单位的高频（HF）功率的HRV与较高的值在睡眠期间。标准化单位的低频（LF）功率和LF/HF比值也显示出显着的昼夜节律在健康受试者，白天较高的值。冠心病患者的心率变异性的标准化频谱成分均无明显的昼夜节律性，并且冠心病患者的LF/HF比值的昼夜差异小于健康人（0.5 ± 1.4 vs 1.81 ± 0.7，P
Background Altered neural regulation of the cardiovascular system may be an important factor for various manifestations of ischemic heart disease. This research was designed to compare the circadian rhythm of cardiac neural regulation and autonomic responses to arousal and upright posture between patients with uncomplicated coronary artery disease (CAD) and age-matched subjects with no evidence of heart disease.Methods and Results Twenty-four-hour heart rate variability (HRV) in the frequency domain was analyzed in 20 male patients (mean age, 52+/-7 years) with angiographic evidence of CAD without prior myocardial infarction and in 20 healthy men (mean age, 51+/-8 years) with no clinical, echocardiographic, or exercise ECG evidence of heart disease. None of the 24-hour average frequency-domain components of HRV differed significantly between the two groups. Healthy subjects had a significant circadian rhythm of normalized units of high-frequency (HF) power of HRV with higher values during sleep. Normalized units of low-frequency (LF) power and the LF/HF ratio also showed a significant circadian rhythm in healthy subjects, with higher values during the daytime. No significant circadian rhythms in any of the normalized spectral components of HRV were observed in patients with CAD, and the night-day difference in LF/HF ratio was smaller in the patients with CAD than in the healthy subjects (0.5+/-1.4 versus 1.81+/-0.7, P