Polysaccharopeptide from Coriolus versicolor has potential for use against human immunodeficiency virus type 1 infection
Polysaccharopeptide from Coriolus versicolor has potential for use against human immunodeficiency virus type 1 infection
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DOI：
10.1016/s0024-3205(97)00294-4
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发表时间：
1997-05-16
期刊：
影响因子：
6.1
通讯作者：
Ng, TB
中科院分区：
文献类型：
--
作者：
Collins, RA;Ng, TB
从杂色云芝(Coriolus Versicolor)中分离得到多糖肽(PSP)，通过一系列体外实验验证了其作为抗人类免疫缺陷病毒1型(HIV-1)化合物的潜力。它能抑制HIV-1gp120与固定化的CD4受体的相互作用(IC50=150mU g/ml)，对重组HIV-1逆转录酶有很强的抑制作用(IC50=6.25mU g/ml)，并能抑制与病毒糖基化有关的糖水解酶。这些性质，再加上它在水中的高度溶解性、热稳定性和低细胞毒性，使其成为一种有用的化合物，可用于进一步研究其作为体内抗病毒药物的可能性。(C)1997年爱思唯尔科学公司。
Polysaccharopeptide (PSP) isolated from the edible mushroom Coriolus versicolor was tested for its potential as an anti-human immunodeficiency virus type 1 (HIV-1) compound in a series of in vitro assays. It demonstrated inhibition of the interaction between HIV-1 gp120 and immobilized CD4 receptor (IC50 = 150 mu g/ml), potent inhibition of recombinant HIV-1 reverse transcriptase (IC50 = 6.25 mu g/ml), and inhibited a glycohydrolase enzyme associated with viral glycosylation. These properties, coupled with its high solubility in water, heat-stability and low cytotoxicity, make it a useful compound for further studies on its possible use as an anti-viral agent in vivo. (C) 1997 Elsevier Science Inc.