Coding the sweet taste in the nucleus of the solitary tract: differential roles for anterior tongue and nasoincisor duct gustatory receptors in the rat.
Coding the sweet taste in the nucleus of the solitary tract: differential roles for anterior tongue and nasoincisor duct gustatory receptors in the rat.
复制标题
在孤束核中编码甜味：大鼠前舌和鼻切管味觉受体的不同作用。
DOI：
10.1152/jn.1991.65.6.1372
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发表时间：
1991
影响因子：
2.5
通讯作者：
Norgren,R
中科院分区：
文献类型：
--
作者：
Travers,SP;Norgren,R
1.人类描述为甜味的各种化学物质在大鼠孤束核（NST）中的驱动神经元在应用于与鼻门齿管（NID）相关的味觉感受器时比应用于前舌（AT）上的味觉感受器时更有力。2.甜刺激施加到AT和NID的不同效果也是明显的，在由这些刺激产生的跨神经元的相关性。对NID刺激的反应比对AT刺激的反应更好地解释了甜味刺激之间的心理物理相似性（对于NID，甜味刺激对之间的平均相关性= +0.70，对于AT =+0.44）。3.葡萄糖的二糖或多糖，即，麦芽糖（0.3 M）和多糖（0.1 M）对NID的刺激作用较差，其引起的反应仅为蔗糖（0.3 M）引起的反应的17.8%和26.7%，而蔗糖是该受体亚群的最佳刺激。这表明多糖和麦芽糖与受体位点相互作用，而这些受体位点与对甜味刺激具有亲和力的受体位点不同。多糖和麦芽糖也是无效的刺激AT，唤起的反应只有11.8%和4.9%的最佳刺激，这个受体亚群，电解质的混合物（0.3 M NaCl，0.03 M HCl，和0.01 M盐酸奎宁）引起的反应大。4.甜味糖在驱动NST神经元中的相对有效性（蔗糖大于果糖大于葡萄糖）与它们在大鼠中产生偏好行为的有效性顺序相关。（250字处删节）
1. A variety of chemicals that humans describe as sweet drive neurons in the nucleus of the solitary tract (NST) of the rat more vigorously when applied to the taste receptors associated with the nasoincisor ducts (NID) than when applied to taste receptors on the anterior tongue (AT). 2. The differential effects of sweet stimuli applied to the AT and NID also are evident in the set of across-neuron correlations produced by these stimuli. The psychophysical similarity among the sweet stimuli is better accounted for by responses to stimulation of the NID than by responses to stimulation of the AT (mean correlation between pairs of sweet stimuli = +0.70 for the NID, +0.44 for the AT). 3. Disaccharides or polysaccharides of glucose, i.e., maltose (0.3 M) and Polycose (0.1 M), are poor stimuli on the NID, evoking responses only 17.8 and 26.7% as great as the response elicited by sucrose (0.3 M), an optimal stimulus for this receptor subpopulation. This suggests that Polycose and maltose interact with receptor sites distinct from those with an affinity for sweet stimuli. Polycose and maltose also are ineffective stimuli on the AT, evoking responses only 11.8 and 4.9% as large as the response evoked by an optimal stimulus for this receptor subpopulation, a mixture of electrolytes (0.3 M NaCl, 0.03 M HCl, and 0.01 M quinine HCl). 4. The relative effectiveness of the sweet sugars in driving NST neurons (sucrose greater than fructose greater than glucose) correlates with their order of effectiveness in generating preference behavior in the rat.(ABSTRACT TRUNCATED AT 250 WORDS)