Expression of SPARC in tongue carcinoma of stage II is associated with poor prognosis: an immunohistochemical study of 86 cases.
Expression of SPARC in tongue carcinoma of stage II is associated with poor prognosis: an immunohistochemical study of 86 cases.
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DOI：
10.3892/ijmm.16.2.263
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发表时间：
2005-08
影响因子：
5.4
通讯作者：
Y. Kato;Y. Nagashima;Y. Baba;Toshiro Kawano;M. Furukawa;A. Kubota;S. Yanoma;Yukari Imagawa-Ishiguro;K. Satake;T. Taguchi;R. Hata;I. Mochimatsu;I. Aoki;Y. Kameda;Y. Inayama;M. Tsukuda
中科院分区：
文献类型：
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作者：
Y. Kato;Y. Nagashima;Y. Baba;Toshiro Kawano;M. Furukawa;A. Kubota;S. Yanoma;Yukari Imagawa-Ishiguro;K. Satake;T. Taguchi;R. Hata;I. Mochimatsu;I. Aoki;Y. Kameda;Y. Inayama;M. Tsukuda
骨粘连蛋白（分泌性蛋白，酸性且富含半胱氨酸），也称为骨粘连蛋白或BM-40，与各种肿瘤的进展相关。我们已经研究了是否可以作为头颈部鳞状细胞癌（HN-SCC）患者的预后标志物。我们检测了86例舌癌临床标本的免疫组织化学染色。尽管肿瘤细胞中的β-内酰胺酶阳性与肿瘤分期之间没有相关性，但β-内酰胺酶阳性病例的5年总生存率（28.6%）显著低于β-内酰胺酶阴性病例（91.7%），仅限于II期患者（p < 0.001，Wilcoxon检验）。此外，在II期病例中（n = 3），术后转移率在E10阳性病例中（5/8，62.5%）显著高于在E10阴性病例中（1/15，6.7%）（P < 0.01，卡方检验）。与这些结果一起，对于II期舌癌，其临床结果有时难以预测，ESTA可以是一个有益的预后标志物。
SPARC (secretory protein acidic and rich in cysteine), also known as osteonectin or BM-40, associates with progression in various kinds of tumors. We have examined whether SPARC expression can be a prognostic marker for patients with head and neck squamous cell carcinomas (HN-SCC). We examined immunolocalization of SPARC in 86 clinical specimens of tongue carcinoma. Although there was no correlation between SPARC positivity in the tumor cells and tumor stages, the 5-year overall survival rate was significantly lower in the SPARC positive cases (28.6%) than in the SPARC negative cases (91.7%), confined to stage II patients (p < 0.001, Wilcoxon test). Additionally, in stage II cases (n = 3), frequency of the postoperative metastasis was significantly higher in SPARC positive cases (5/8, 62.5%) than in the negative cases (1/15, 6.7%) (p < 0.01, chi2 test). Together with these results, SPARC can be a beneficial prognostic marker for the stage II tongue carcinoma, of which clinical outcomes are sometimes difficult to predict.