Hippocampal volume and everyday memory in children of very low birth weight
Hippocampal volume and everyday memory in children of very low birth weight
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DOI：
10.1203/00006450-200006000-00006
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发表时间：
2000-06-01
影响因子：
3.6
通讯作者：
Gadian, DG
中科院分区：
文献类型：
--
作者：
Isaacs, EB;Lucas, A;Gadian, DG
早产儿和出生体重极低的儿童学习困难的发生率增加，但对其认知缺陷的具体性质和潜在的神经病理学知之甚少。我们假设，由于海马体在这一认知领域的作用，他们对缺氧、代谢和营养损伤的脆弱性会导致海马体积减少和记忆缺陷。使用神经心理学和磁共振成像方法在早产（小于或等于妊娠 30 周，n = 11）或足月（n = 8）的青少年中研究这一假设。尽管头部大小相同，早产组的双侧海马体积明显较小，但根据客观测试和父母问卷调查显示，酸在日常记忆的某些方面表现出特定的缺陷。早产儿组在计算能力方面也存在特殊缺陷。海马体积的减少和日常记忆的缺陷以前未被认识到，但它们在一组神经系统正常的儿童中的患病率是惊人的。
Children born preterm and of very low birth weight have an increased incidence of learning difficulties, but little is known about the specific nature of their cognitive deficits and the underlying neuropathology. We hypothesized that their vulnerability to hypoxic, metabolic, and nutritional insults would lead to reduced hippocampal volumes and to deficits in memory because of the role of the hippocampus in this domain of cognition. Neuropsychological and magnetic resonance imaging methods were used to investigate this hypothesis in adolescents born preterm (less than or equal to 30 wk gestation, n = 11) or full-term (n = 8). The preterm group had significantly smaller hippocampal volumes bilaterally, despite equivalent head size, acid showed specific deficits in certain aspects of everyday memory, both on objective testing and as indicated by parental questionnaires. The preterm group also had a specific deficit in numeracy. The reduced hippocampal volumes and deficits in everyday memory have previously been unrecognized, but their prevalence in a group of neurologically normal children is striking.