The ventral hippocampus is necessary for expressing a spatial memory
The ventral hippocampus is necessary for expressing a spatial memory
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DOI：
10.1007/s00429-011-0332-y
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
de Vasconcelos, Anne Pereira
中科院分区：
文献类型：
--
作者：
Loureiro, Michael;Lecourtier, Lucas;de Vasconcelos, Anne Pereira
目前的观点认为背海马（DHipp）有助于空间记忆过程。相反，腹侧海马（VHipp）调节压力，情绪和影响。支持这种分离的论据包括（i）连接性的差异：DHipp与接收视觉空间新皮层输入的内嗅皮层相连; VHipp与杏仁核和下丘脑相连，（ii）电生理特征：DHipp的位置细胞比例大于VHipp，位置野的大小呈背腹向梯度增加，提示VHipp中的空间编码不太精细，以及（iii）病变的后果：DHipp病变后空间记忆改变，VHipp病变后不太明显，有时不改变。使用可逆失活，我们报告在大鼠中，利多卡因注入到DHipp或VHipp的权利之前，探针试验损害检索性能在水迷宫任务。这种损害被发现在两个收购后延迟兼容最近的记忆（1和5天）。训练前阻断VHipp并没有阻止任务获取和无药物检索，相反，训练前阻断DHipp，这改变了随后的无药物探针试验的性能。补充实验排除了可能的运动，感觉运动，动机或焦虑相关的数据解释的偏见。我们的结论是，空间记忆可以获得与DHipp，不太有效地与VHipp，和检索这样的记忆和/或其表示的表达从事海马体的背腹轴时，任务已经学会了一个完全功能性的海马体。
Current views posit the dorsal hippocampus (DHipp) as contributing to spatial memory processes. Conversely, the ventral hippocampus (VHipp) modulates stress, emotions and affects. Arguments supporting this segregation include differences in (i) connectivity: the DHipp is connected with the entorhinal cortex which receives visuospatial neocortical inputs; the VHipp is connected with both the amygdala and hypothalamus, (ii) electrophysiological characteristics: there is a larger proportion of place cells in the DHipp than in the VHipp, and an increasing dorsoventral gradient in the size of place fields, suggesting less refined spatial coding in the VHipp, and (iii) consequences of lesions: spatial memory is altered after DHipp lesions, less dramatically, sometimes not, after VHipp lesions. Using reversible inactivation, we report in rats, that lidocaine infusions into the DHipp or VHipp right before a probe trial impair retrieval performance in a water-maze task. This impairment was found at two post-acquisition delays compatible with recent memory (1 and 5 days). Pre-training blockade of the VHipp did not prevent task acquisition and drug-free retrieval, on the contrary to pre-training blockade of DHipp, which altered performance in a subsequent drug-free probe trial. Complementary experiments excluded possible locomotor, sensorimotor, motivational or anxiety-related biases from data interpretation. Our conclusion is that a spatial memory can be acquired with the DHipp, less efficiently with the VHipp, and that the retrieval of such a memory and/or the expression of its representation engages the dorsoventral axis of the hippocampus when the task has been learnt with an entirely functional hippocampus.