TUTORIAL IN BIOSTATISTICS SURVIVAL ANALYSIS IN OBSERVATIONAL STUDIES
TUTORIAL IN BIOSTATISTICS SURVIVAL ANALYSIS IN OBSERVATIONAL STUDIES
复制标题
观察性研究中的生物统计学生存分析教程
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
D. Spiegelhalter
中科院分区：
文献类型：
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作者：
K. Bull;D. Spiegelhalter
多中心数据库对医学理解的贡献越来越大。虽然随机实验研究的统计处理在医学文献中有很好的记录，但观察性研究的分析需要处理与研究的进入时间和在此之后才引入的潜在解释变量的影响有关的其他重要问题。用一个小数据集说明了一系列的分析。单一和多个解释变量对固定时间间隔后的结果和对特定事件发生前的生存时间的影响。分析仅在随访中起作用的因素对生存率的影响。讨论了每项分析的目的、所用数据的选择、方法的要点、结果的解释以及局限性和基本假设。值得强调的是，与随机研究相比，观察性研究中干预措施的选择和时机的基础没有精确规定，因此将生存影响归因于干预措施必须是试探性的。提供了术语表。（John Wiley & Sons, Ltd., 1997）医学统计，第16卷，1041-1074（1997）。
SUMMARY Multi-centre databases are making an increasing contribution to medical understanding. While the statistical handling of randomized experimental studies is well documented in the medical literature, the analysis of observational studies requires the addressing of additional important issues relating to the timing of entry to the study and the e⁄ect of potential explanatory variables not introduced until after that time. A series of analyses is illustrated on a small data set. The influence of single and multiple explanatory variables on the outcome after a fixed time interval and on survival time until a specific event are examined. The analysis of the e⁄ect on survival of factors that only come into play during follow-up is then considered. The aim of each analysis, the choice of data used, the essentials of the methodology, the interpretation of the results and the limitations and underlying assumptions are discussed. It is emphasized that, in contrast to randomized studies, the basis for selection and timing of interventions in observational studies is not precisely specified so that attribution of a survival e⁄ect to an intervention must be tentative. A glossary of terms is provided. ( 1997 by John Wiley & Sons, Ltd. Stat. Med., Vol. 16, 1041—1074 (1997).
DOI：
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发表时间：
1995
期刊：
Medical care.
影响因子：
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作者：
D'Agostino,RB;Kwan,H
通讯作者：
Kwan,H
影响因子：
2
作者：
DAGOSTINO, RB;LEE, ML;KANNEL, WB
通讯作者：
KANNEL, WB