Bone Mineral Density of the Spine Using Dual Energy X‐Ray Absorptiometry in Patients with Non‐Insulin‐Dependent Diabetes Mellitus
Bone Mineral Density of the Spine Using Dual Energy X‐Ray Absorptiometry in Patients with Non‐Insulin‐Dependent Diabetes Mellitus
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DOI：
10.1111/j.1447-0756.1996.tb00959.x
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发表时间：
1996-04
影响因子：
1.6
通讯作者：
D. Kwon;Jim‐Hong Kim;K. Chung;Jang‐Heub Kim;Jinwoo Lee;Soo‐Pyung Kim;H. Lee
中科院分区：
文献类型：
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作者：
D. Kwon;Jim‐Hong Kim;K. Chung;Jang‐Heub Kim;Jinwoo Lee;Soo‐Pyung Kim;H. Lee
为了评价非胰岛素依赖型糖尿病（NIDDM）对骨密度（BMD）的影响，我们使用双能X线吸收法（DEXA）测量了185例女性NIDDM患者的BMD。测量腰椎（L2-4）的BMD。与对照组相比，糖尿病患者的BMD略高，与绝经相关的骨丢失在绝经前开始。绝经后妇女的BMD随增龄而明显下降，55岁以后出现突然性骨丢失（P < 0.05）。与糖尿病病程有关，15年的BMD下降为10.0%。BMD与年龄、绝经年限（YSM）和病程呈负相关（r =-0.584，r =-0.470，r =-0.186）。提示年龄、YSM、病程是糖尿病患者骨密度降低的危险因素。
To evaluate the influence of non‐insulin‐dependent diabetes mellitus (NIDDM) on bone mineral density (BMD), we measured BMD in 185 female patients with NIDDM using dual energy X‐ray absorptiometry (DEXA). BMD was measured in lumbar vertebrae (L2–4). BMD is slightly higher in the diabetic patients compared with control subjects and bone loss related to menopause starts before the onset of menopause. The BMD of postmenopausal women showed a definite decrease with aging and there was abrupt bone loss after 55 years of age (p < 0.05). In relation to the duration of diabetes, the decrease of BMD for 15 years was 10.0%. BMD was negatively correlated with age, years since menopause (YSM), and disease duration (r = ‐ 0.584, r = ‐ 0.470, r = ‐0.186). These results suggest that age, YSM, and the duration of disease appear to be the risk factors for decreased BMD in the diabetic patients.