COMPARISON OF MUCUS GLANDS IN THE TRACHEOBRONCHIAL TREE OF MAN AND ANIMALS *
COMPARISON OF MUCUS GLANDS IN THE TRACHEOBRONCHIAL TREE OF MAN AND ANIMALS *
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人和动物气管支气管树中粘液腺的比较*
DOI：
10.1111/j.1749-6632.1963.tb16665.x
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发表时间：
1963
影响因子：
5.2
通讯作者：
O. Brantigan
中科院分区：
文献类型：
--
作者：
R. V. Goco;M. Kress;O. Brantigan
确诊的原发性特发性阻塞性肺气肿患者的症状表现为呼吸困难和恼人的早晨咳嗽，并伴有少量顽固性痰，而且极难咳出。最轻微的劳累，如早晨准备厕所，剃须，刷牙和洗澡，通常伴随着呼吸困难和疲惫。这些患者在由肺体积减小组成的外科手术之后，通过切除功能上无用的肺组织和通过支气管肺系统的去神经支配，显示出显著的临床改善>”痰液粘性较低并且更容易排出。随后呼吸的改善使这些患者能够照顾自己。由于肺功能的改善，这些患者中的许多人从肺残疾转变为健康状态，使他们能够重返有用的职业。看来，改善的一个重要因素是由于未感染的支气管分泌物的性质发生了变化，这是由支气管腺体萎缩引起的，这是支气管平滑肌去神经支配的结果。研究支气管肺动脉去神经支配对支气管腺体的影响的愿望刺激了正在进行的工作。
Patients with well-established primary idiopathic obstructive pulmonary emphysema present symptoms characterized by dyspnea and annoying morning cough productive of a small amount of tenacious sputum, which is expectorated with extreme difficulty. The slightest exertion, such as preparing the morning toilet, shaving, brushing the teeth, and bathing, is usually accompanied by dyspnea and exhaustion. These patients, after a surgical procedure consisting of the reduction of the lung volume, by resecting functionally useless lung tissue and by denervation of the bronchopulmonary system, show significant clinical improvement>” The sputum is less viscid and more easily expelled. The improvement in breathing that follows enables these patients to care for themselves. Many of these patients are converted from pulmonary cripples to a state of well-being which permits them to return to useful occupation as a result of improvement in their pulmonary function. I t seems that a significant factor in the improvement is due to a change in the character of the uninfected bronchial secretion which is brought about by atrophy of the bronchial glands, a result of the bronchopulmonary denervation. A desire to study the effects of bronchopulmonary denervation on the bronchial glands stimulated the work that is being presented.