MOLECULAR AND PHENOTYPIC VARIATION IN THE ACHAETE-SCUTE REGION OF DROSOPHILA-MELANOGASTER
MOLECULAR AND PHENOTYPIC VARIATION IN THE ACHAETE-SCUTE REGION OF DROSOPHILA-MELANOGASTER
复制标题
DOI：
10.1038/348064a0
复制
发表时间：
1990-11-01
期刊：
影响因子：
64.8
通讯作者：
LANGLEY, CH
中科院分区：
文献类型：
--
作者：
MACKAY, TFC;LANGLEY, CH
数量性状的变异是许多适应性进化的基础，并为家养物种的选择性改良提供了基础，但数量变异的遗传本质尚不清楚。许多影响数量性状的基因座是通过分离具有主效应质效应的突变等位基因2、3来确定的。这些等位基因可能代表了等位基因效应连续体的一个极端，大多数数量变异可能是由主效应基因4-6所确定的等位基因的微效等位基因的分离所致。果蝇的毛状复合体在刚毛发育中起着中心作用7、8，并已在分子水平9、10上被描述。通过将毛数的表型变异与从自然种群中提取的该区域染色体的分子变异联系起来，验证了毛数自然发生的数量变异可能与野生型等位基因有关的假说。毛刺区的DNA插入变异与刷毛数量的变异密切相关。
VARIATION in quantitative characters underlies much adaptive evolution and provides the basis for selective improvement of domestic species, yet the genetic nature of quantitative variation is poorly understood1. Many loci affecting quantitative traits have been identified by the segregation of mutant alleles with major qualitative effects2,3. These alleles may represent an extreme of a continuum of allelic effects, and most quantitative variation could result from the segregation of alleles with subtle effects at loci identified by alleles with major effects4–6. Theachaete-scutecomplex inDrosophila melanogasterplays a central part in bristle development7,8and has been characterized at the molecular level9,10. The hypothesis that naturally occurring quantitative variation in bristle number could be associated with wild-type alleles ofachaete-scutewas tested by correlating phenotypic variation in bristle number with molecular variation in restriction maps in this region among chromosomes extracted from natural populations. DNA insertion variation in theachaete-scuteregion was found to be strongly associated with variation in bristle number.