A cognitive and neurophysiological test of change from an individual's baseline
A cognitive and neurophysiological test of change from an individual's baseline
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DOI：
10.1016/j.clinph.2010.06.010
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发表时间：
2011-01-01
影响因子：
4.7
通讯作者：
Abraham, Gordon
中科院分区：
文献类型：
--
作者：
Gevins, Alan;Smith, Michael E.;Abraham, Gordon
目的：提出一种自动认知神经生理学测试，其特征在于个体如何受到药物或治疗的影响。该测试计算工作记忆任务表现、皮层激活和警觉性的子分数，并将子分数组合成总分。方法：该测试应用于16名健康成年人的酒精、咖啡因、苯海拉明和睡眠剥夺的双盲、安慰剂对照研究。安慰剂组分项评分和总分的日间和日内变异性均接近于零，表明评分稳定。所有的治疗影响的整体分数，而差异的影响分突出了EEG measurements.Conclusions的附加值：测试是敏感的认知功能相对温和的改变。它的自动化使其适用于大规模的临床试验。意义：通过将任务表现与EEG脑功能测量相结合，该测试可能被证明在检测药物或其他治疗引起的变化方面比不直接测量脑功能信号的可比神经心理学测试电池具有更好的灵敏度和特异性。(C)2010年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: An automated cognitive neurophysiological test is presented that characterizes how an individual was affected by a drug or treatment. The test calculates sub-scores for working memory task performance, cortical activation, and alertness, and combines the sub-scores into an overall score.Methods: The test was applied in a double-blind, placebo-controlled study of alcohol, caffeine, diphenhydramine, and sleep deprivation in 16 healthy adults.Results: The between- and within-day variability of the sub-scores and overall scores for placebo were all near zero, suggesting that the scores are stable. All treatments affected the overall score, while differential effects on sub-scores highlighted the added value of EEG measures.Conclusions: The test is sensitive to relatively mild alterations in cognitive function. Its automation makes it suitable for use in large-scale clinical trials.Significance: By combining task performance with EEG brain function measures, the test may prove to have better sensitivity and specificity in detecting changes due to drugs or other treatments than comparable neuropsychological test batteries that do not directly measure brain function signals. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.