Comparison of antibody responses after vaccination with two inactivated rabies vaccines
Comparison of antibody responses after vaccination with two inactivated rabies vaccines
复制标题
DOI：
10.1016/j.vetmic.2008.06.024
复制
发表时间：
2009-01-13
影响因子：
3.3
通讯作者：
Guigal, P. M.
中科院分区：
文献类型：
--
作者：
Minke, J. M.;Bouvet, J.;Guigal, P. M.
将 30 只实验犬随机分为两组（A 和 B），每组 15 只，并皮下接种两种市售单价灭活狂犬病疫苗之一的单剂疫苗：RABISIN(1)（法国梅里亚）（A 组）和 NOBIVAC(2) 狂犬病疫苗（Intervet International）（B 组）。使用荧光抗体病毒中和 (FAVN) 测试在 4 个月的时间内测量狂犬病抗体。这两种疫苗在狗体内狂犬病抗体滴度的大小和持久性方面表现不同。接种疫苗两周后，A 组和 B 组狗的平均狂犬病抗体滴度峰值分别为 2.53 IU/mL（范围：0.17-13.77 IU/mL）和 1.26 IU/mL（范围：0.50-4.56 IU/mL）。 D28、D56、D84、D112 和 D120 时，A 组的平均 FAVN 狂犬病抗体滴度显着高于 B 组。尽管 B 组的所有狗对疫苗接种均产生血清学反应，但抗体滴度 >= 0.5 IU/mL 的狗的比例在 D28 后显着下降，并且与 A 组狗相比，在 D56、D84 和 D112 具有统计学意义的显着降低。总之，在国际贸易背景下，疫苗的选择和血液检测的时机是狂犬病疫苗接种后能否获得成功的血清学检测结果的关键因素。 RABISIN 可诱导针对狂犬病的高且持续的抗体滴度，增加初次疫苗接种后采血时间的灵活性。 (C) 2008 Elsevier B.V. 保留所有权利。
Thirty laboratory dogs were randomly assigned to two groups (A and B) of 15 dogs and subcutaneously vaccinated with a single dose of one of two commercially available monovalent inactivated rabies vaccines: RABISIN(1) (Merial, France) (group A) and NOBIVAC(2) Rabies (Intervet International) (group B). Rabies antibodies were measured over a period of 4 months using the fluorescent antibody virus neutralization (FAVN) test. The two vaccines performed differently in terms of magnitude and persistence of rabies antibodies titers in dogs. Two weeks after vaccination, average rabies antibody titers peaked at 2.53 IU/mL (range, 0.17-13.77 IU/mL) and 1.26 IU/mL (range, 0.50-4.56 IU/mL) in groups A and B dogs, respectively. The average FAVN antibody titres against rabies on D28, D56, D84, D112 and D120 were significantly higher in group A than in group B. Although all dogs from group B serologically responded to vaccination, the proportion of dogs with antibody titres >= 0.5 IU/mL dropped significantly after D28 and was statistically significantly lower on D56, D84 and D112 compared to group A dogs. In conclusion, in the context of international trade, the choice of the vaccine and the timing of blood tests are critical factors in achieving successful serological test results after rabies vaccination. RABISIN induces high and sustained antibody titres against rabies, increasing the flexibility for the time of blood sampling after primo-vaccination. (C) 2008 Elsevier B.V. All rights reserved.