Cytological features of basal cell adenocarcinoma of the salivary glands.
Cytological features of basal cell adenocarcinoma of the salivary glands.
复制标题
唾液腺基底细胞腺癌的细胞学特征。
DOI：
10.1002/dc.24178
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Tsuta K
中科院分区：
文献类型：
--
作者：
Ishida M;Okano K;Sandoh K;Ebisu Y;Fujisawa T;Iwai H;Tsuta K
摘要涎腺基底细胞腺癌是一种罕见的恶性肿瘤，其细胞学特征尚未被充分描述。本研究纳入了经组织病理学诊断为BAC并接受术前细针穿刺细胞学检查的患者。细胞学特征，包括背景，安排和肿瘤细胞的形状，核和胞质的特点，以及间质梭形细胞的存在，进行了审查。7例患者入组研究。细胞学标本是细胞性的，由大或小的簇组成，偶尔在周围有松散的肿瘤细胞。4例病例的主要细胞形态为梭形，3例病例为小圆形。这些肿瘤细胞紧密堆积，显示出高细胞性和重叠的核，并具有轻度至中度增大的圆形至椭圆形核，偶尔有小核仁和少量细胞质。3例（42.9%）基底细胞周围可见间质梭形细胞。所有经组织学证实的间质梭形细胞阳性病例的细胞学标本中都有间质梭形细胞。研究结果清楚地表明，在BAC的细胞学标本中，间质梭形细胞的频率相对较高。尽管涎腺基底细胞腺瘤的细胞学标本中经常有间质梭形细胞，但这一发现是BAC的特征。BAC与基底细胞腺瘤的区别特征是存在紧密堆积的高细胞簇和松散的肿瘤细胞。了解这些细胞学特征有助于BAC的细胞学诊断。
The cytological features of basal cell adenocarcinoma (BAC) of the salivary gland, a rare carcinoma, have not been well described. This study included patients who were histopathologically diagnosed with BAC and who underwent preoperative fine‐needle aspiration cytological examination. Cytological characteristics, including background, arrangement and shape of the neoplastic cells, nuclear and cytoplasmic features, and presence of stromal spindle cells, were reviewed. Seven patients were enrolled in the study. The cytological specimens were cellular and composed of large or small clusters with occasional discohesive neoplastic cells at the periphery. The predominant cellular morphology was spindle‐shaped in four cases, and small round‐shaped in three cases. These neoplastic cells were tightly packed, showed high cellularity and overlapping nuclei, and had mildly to moderately enlarged round to oval nuclei with occasional small nucleoli and scant cytoplasm. Stromal spindle cells were observed around the basaloid cells in three cases (42.9%). All histology‐proven stromal spindle cell‐positive cases had stromal spindle cells in the cytological specimens. The study findings clearly demonstrate the relatively high frequency of stromal spindle cells in cytological specimens of BAC. This finding is characteristic of BAC, although basal cell adenoma of salivary gland frequently has stromal spindle cells in the cytological specimens. The characteristic that differentiates BAC from basal cell adenoma is the presence of tightly packed and high cellular clusters with discohesive neoplastic cells. An understanding of these cytological features can aid the cytodiagnosis of BAC.