Efficacy of Cyclosporine 0.05% Eye Drops in Stevens Johnson Syndrome with Chronic Dry Eye
Efficacy of Cyclosporine 0.05% Eye Drops in Stevens Johnson Syndrome with Chronic Dry Eye
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DOI：
10.1089/jop.2012.0009
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发表时间：
2013-04-01
影响因子：
2.3
通讯作者：
Kasemson, Sirilux
中科院分区：
文献类型：
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作者：
Prabhasawat, Pinnita;Tesavibul, Nattaporn;Kasemson, Sirilux
目的：评价0.05%环孢霉素（CsA）滴眼液对患有慢性干眼的Stevens约翰逊综合征（SJS）患者的疗效。设计：前瞻性非比较性干预病例系列。方法：30例SJS患者发生干眼，通过症状和体征定义，包括Schirmer I试验，荧光素清除试验（FCT），和角膜染色（荧光素和玫瑰红染色）用0.05% CsA滴眼液每日2次治疗6个月。在治疗前和治疗后0、2、4和6个月评价干眼症状、眼内注射、泪膜破裂时间（TBUT）和角膜染色。在0个月和6个月时评估Shirmer I测试和FCT。结果：17名患者（56.67%）完成了研究。8例患者（26.67%）由于CsA的无法耐受的副作用（包括疼痛、发红和眼睑肿胀）而退出研究。5例失访。17例患者的干眼症状、结膜充血、角膜染色、Schirmer I试验和FCT均明显改善（P < 0.05）。
Objective: To evaluate the efficacy of cyclosporine 0.05% (CsA) eye drops in patients with Stevens Johnson syndrome (SJS) who had chronic dry eye.Design: Prospective noncomparative interventional case series.Methods: Thirty cases of SJS patients who developed dry eye defined by symptoms and signs, including the Schirmer I test, the fluorescein clearance test (FCT), and corneal staining (fluorescein and Rose Bengal staining) were treated with CsA 0.05% eye drops twice daily for 6 months. Dry eye symptoms, eye injection, tear break up time (TBUT), and corneal staining were evaluated before and after the treatment at 0, 2, 4, and 6 months. The Shirmer I test and FCT were evaluated at 0 and 6 months.Results: Seventeen patients (56.67%) completed the study. Eight patients (26.67%) withdrew from the study as a result of intolerable side effects of CsA, which included pain, redness, and eyelid swelling. Five cases were lost in follow up. All 17 cases demonstrated significant improvement in dry eye symptoms, conjunctival injection, corneal staining, Schirmer I test, and FCT (P < 0.05).Conclusions: CsA 0.05% eye drops might be beneficial in the treatment of chronic dry eye associated with SJS.