POSTTRAUMATIC AUTOIMMUNE REACTION IN PERIPHERAL-NERVE - EFFECT OF A SINGLE INJURY
POSTTRAUMATIC AUTOIMMUNE REACTION IN PERIPHERAL-NERVE - EFFECT OF A SINGLE INJURY
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DOI：
10.1016/0014-4886(85)90199-2
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发表时间：
1985-01-01
影响因子：
5.3
通讯作者：
WANG, YN
中科院分区：
文献类型：
--
作者：
DEMEDINACELI, L;CHURCH, AC;WANG, YN
本研究表明，大鼠坐骨神经单次损伤后可观察到局部自身免疫反应。此外，我们试图将免疫反应的强度与神经损伤的严重程度、手术治疗的类型和功能恢复的程度联系起来。通过使用直接免疫荧光技术，我们发现最初损伤的严重程度与手术后2.5个月评估的局部免疫反应的强度有关。手术治疗的类型和自身免疫反应的强度之间存在关联。目前尚不清楚自身免疫反应与长期功能损害程度之间的相关性。对这些结果背后的可能因素进行了讨论。
This study was conducted to show that local autoimmune reactions could be observed in rat sciatic nerve after a single injury. Furthermore, we attempted to correlate the intensity of the immunological reaction with the severity of nerve damage, with the type of surgical treatment and with the degree of functional recovery. Through the use of direct immunofluorescence techniques, we found that the severity of the initial damage was associated with the intensity of the local immunological response assessed 2.5 months after surgery. There was an association between type of surgical treatment and intensity of the autoimmune reaction. A correlation between autoimmune reaction and degree of long-term functional impairment was not immediately clear. The probable factors that underlie these results are discussed.