A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina
A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina
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DOI：
10.7554/elife.58995
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发表时间：
2020-08-25
期刊：
影响因子：
7.7
通讯作者：
Brauner, Colin J.
中科院分区：
文献类型：
--
作者：
Damsgaard, Christian;Lauridsen, Henrik;Brauner, Colin J.
此前，我们发现鱼类高视力的进化与其独特的对pH敏感的血红蛋白直接相关，这种血红蛋白允许O-2在PO(2)时被输送到视网膜，是动脉血的十倍以上(Damsgaard等人，2019年)。在这里，我们展示了强有力的证据表明，供应视网膜的血管结构中的空泡型H+-ATPase和血浆可及的碳酸氢酶共同作用，使红细胞酸化，导致O-2的分泌。体内数据表明，这一途径主要影响参与信号处理和转导的视网膜内部的氧合作用，并且这一途径的演变与视网膜内部的形态扩张密切相关。我们得出结论，这种视网膜氧合机制在硬骨鱼视觉的适应性进化中发挥了至关重要的作用。
Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O-2 to be delivered to the retina at PO(2)s more than ten-fold that of arterial blood (Damsgaard et al., 2019). Here, we show strong evidence that vacuolar-type H+-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying the retina act together to acidify the red blood cell leading to O-2 secretion. In vivo data indicate that this pathway primarily affects the oxygenation of the inner retina involved in signal processing and transduction, and that the evolution of this pathway was tightly associated with the morphological expansion of the inner retina. We conclude that this mechanism for retinal oxygenation played a vital role in the adaptive evolution of vision in teleost fishes.