Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
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DOI：
10.1038/nn.4053
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发表时间：
2015-08
影响因子：
25
通讯作者：
Mogil JS
中科院分区：
文献类型：
--
作者：
Sorge RE;Mapplebeck JC;Rosen S;Beggs S;Taves S;Alexander JK;Martin LJ;Austin JS;Sotocinal SG;Chen D;Yang M;Shi XQ;Huang H;Pillon NJ;Bilan PJ;Tu Y;Klip A;Ji RR;Zhang J;Salter MW;Mogil JS
大量且迅速增加的证据表明，小胶质细胞-神经元信号传导对于慢性疼痛超敏性至关重要。在这里，我们使用多种方法表明，小胶质细胞不是雌性小鼠机械性疼痛超敏反应所必需的;雌性小鼠使用适应性免疫细胞（可能是T淋巴细胞）实现类似水平的疼痛超敏反应。这种两性异形表明，在疼痛研究中，雄性小鼠不能作为雌性小鼠的替代品。
A large and rapidly increasing body of evidence indicates that microglia-neuron signaling is essential for chronic pain hypersensitivity. Here we show using multiple approaches that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieve similar levels of pain hypersensitivity using adaptive immune cells, likely T-lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.