Dietary fat and the risk of clinical type 2 diabetes - The European Prospective Investigation of Cancer-Norfolk study
Dietary fat and the risk of clinical type 2 diabetes - The European Prospective Investigation of Cancer-Norfolk study
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DOI：
10.1093/aje/kwh004
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发表时间：
2004-01-01
影响因子：
5
通讯作者：
Wareham, NJ
中科院分区：
文献类型：
--
作者：
Harding, AH;Day, NE;Wareham, NJ
饮食脂肪在2型糖尿病病因学中的作用仍然不确定。作者在欧洲癌症前瞻性调查-诺福克研究中调查了膳食脂肪组成与临床2型糖尿病风险之间的关系，并确定了与膳食脂肪组成相关的食物消费模式。在基线（1993-1997年）使用半定量食物频率问卷对饮食进行评估。从多种信息来源，在3-7年的随访期间，在23，631名年龄在40-78岁的男性和女性中确定了414例糖尿病事件。捕获-再捕获确定水平为99%。经能量调整的膳食多不饱和脂肪：饱和脂肪比例与糖尿病风险呈负相关（比值比（OR）= 0.84/标准差变化，95%置信区间（CI）：0.75，0.94）。调整年龄、性别、糖尿病家族史、吸烟、体力活动、总脂肪、蛋白质和酒精后，这种关联减弱（OR = 0.88，95%CI：0.78，0.99），在包括体重指数和腰臀比后，这种关联不再具有统计学意义（OR = 0.91，95%CI：0.81，1.03）。这项前瞻性研究表明，饮食中多不饱和脂肪：饱和脂肪比例的增加与糖尿病风险的降低有关，与年龄，性别，糖尿病家族史和其他生活方式因素无关。
The role of dietary fat in the etiology of type 2 diabetes remains uncertain. The authors investigated the association between dietary fat composition and risk of clinical type 2 diabetes in the European Prospective Investigation of Cancer-Norfolk study and identified food consumption patterns associated with dietary fat composition. Diet was assessed at baseline (1993-1997) using a semiquantitative food frequency questionnaire. From multiple sources of information, 414 incident cases of diabetes were identified among 23,631 men and women aged 40-78 years during 3-7 years of follow-up. The capture-recapture ascertainment level was 99%. The energy-adjusted dietary polyunsaturated:saturated fat ratio was inversely associated with the risk of diabetes (odds ratio (OR) = 0.84 per standard deviation change, 95% confidence interval (CI): 0.75, 0.94). Adjustment for age, sex, family history of diabetes, smoking, physical activity, total fat, protein, and alcohol attenuated the association (OR = 0.88, 95% CI: 0.78, 0.99), and it was no longer statistically significant after including body mass index and the waist:hip ratio (OR = 0.91, 95% CI: 0.81, 1.03). This prospective study showed that an increased dietary polyunsaturated:saturated fat ratio was associated with a reduced risk of diabetes, independent of age, sex, family history of diabetes, and other lifestyle factors.