Construction of Vicinal Quaternary Carbon Centers via Cobalt-Catalyzed Asymmetric Reverse Prenylation.
Construction of Vicinal Quaternary Carbon Centers via Cobalt-Catalyzed Asymmetric Reverse Prenylation.
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DOI：
10.1021/acs.orglett.8b04030
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发表时间：
2019-02
期刊：
影响因子：
5.2
通讯作者：
Minghe Sun;Jia-Feng Chen;Shufeng Chen;Changkun Li
中科院分区：
文献类型：
--
作者：
Minghe Sun;Jia-Feng Chen;Shufeng Chen;Changkun Li
本文报道了钴催化的β-酮酯与叔烯丙基碳酸酯的高对映选择性的异戊烯化反应，以构建邻位全碳季碳中心。采用锌还原原位生成的钴/（S，S）Ph-BPE络合物，获得了优良的支化-直链选择性（>20：1）和高达92%ee。
A highly enantioselective cobalt-catalyzed reverse prenylation of β-ketoester with tertiary allylic carbonate to construct vicinal all-carbon quaternary carbon centers has been developed. By using the cobalt/( S, S)Ph-BPE complex generated in situ with zinc reduction, excellent branched to linear selectivity (>20:1) and up to 92% ee have been obtained.