Relationship between atopic dermatitis and children's mental and behavioral health: The Hokkaido Study
Relationship between atopic dermatitis and children's mental and behavioral health: The Hokkaido Study
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特应性皮炎与儿童的关系
DOI：
10.11236/jph.67.10_745
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Reiko Kishi
中科院分区：
文献类型：
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作者：
Machiko Minatoya;Satoshi Suyama;Reiko Kishi
目的特应性皮炎是一种儿童常见病，发病率呈上升趋势，严重影响儿童的生活质量。阿尔茨海默病在早期发病可能会扰乱正常的睡眠模式、行为和人际关系。与AD相关的越来越多的行为和纪律问题已经被记录在案。然而，对早期阿尔茨海默病的研究不足，特别是在日本。本研究旨在探讨AD与学龄前儿童心理和行为健康的关系。方法本研究是前瞻性队列研究的一部分(n=20926)，2008年4月以后出生的儿童(n=7386)为本研究的目标人群。在4岁时回答国际儿童哮喘和过敏症研究(ISAC)日本版(n=4,228)并在5岁时回答力量和困难问卷(SDQ)的人被纳入本研究(n=3,862)。研究SDQ中情绪症状、品行问题、同伴关系问题、多动/注意力不集中4个子量表分及其总分(TDS)与AD患病率的关系。SDQ评分作为连续值进行线性回归分析，作为二分值进行Logistic回归分析。在最终的模型中调整了AD的父母病史。结果799例4岁儿童AD患病率为20.7%。阿尔茨海默病儿童的情绪症状、行为问题和TDS均分显著高于非阿尔茨海默病儿童。线性回归分析显示，与AD相关的情绪症状、行为问题和TDS得分增加。Logistic回归分析显示AD儿童行为问题的风险显著增加。结论本研究发现4岁时AD与情绪症状、品行问题及5岁时的TDS有关。进一步的研究以评估AD的严重程度以及儿童在较大年龄时的精神和行为问题是至关重要的。
Objectives Atopic dermatitis (AD) is a common childhood disease with an increasing prevalence, affecting the quality of life of afflicted children. The onset of AD at an early age may disrupt normal sleep patterns, behavior, and relationships. Increased behavioral and discipline problems associated with AD have been documented. However, there are insufficient studies on AD at early ages, especially in Japan. This study aimed to examine the association between AD and the mental and behavioral health of children of preschool age. Methods This study was a part of a prospective cohort study (n= 20,926), and children born after April 2008 (n= 7,386) were the target population of this study. Those who answered the Japanese version of the International Study of Asthma and Allergies in Childhood (ISAAC) at 4 years of age (n= 4,228) and answered the Strength and Difficulties Questionnaire (SDQ) at 5 years of age were included in this study (n= 3,862). The subscale scores of SDQ, namely, emotional symptoms, conduct problems, peer relationship problems, and hyperactivity/inattention, along with the sum of these 4 subscale scores,(total difficulties score (TDS), were investigated in relation to the prevalence of AD. SDQ scores were treated as continuous values for linear regression analysis and as dichotomized values for logistic regression analysis. The parental history of AD was adjusted in the final models. Results The prevalence of AD at 4 years of age was 20.7%(n= 799). The mean scores of emotional symptoms, conduct problems, and TDS were significantly higher among children with AD than among those without AD. Linear regression analysis revealed increased scores for emotional symptoms, conduct problems, and TDS in association with AD. Logistic regression analysis revealed a significantly increased risk for conduct problems in children with AD. Conclusion This study found associations between AD at 4 years of age and emotional symptoms, conduct problems and TDS at 5 years of age. Further studies to assess the severity of AD and children's mental and behavioral problems at older ages are essential.