Peripapillary Vessel Density as Early Biomarker in Multiple Sclerosis
Peripapillary Vessel Density as Early Biomarker in Multiple Sclerosis
复制标题
DOI：
10.3389/fneur.2020.00542
复制
发表时间：
2020-06-17
影响因子：
3.4
通讯作者：
Brescia Morra, Vincenzo
中科院分区：
文献类型：
--
作者：
Cennamo, Gilda;Carotenuto, Antonio;Brescia Morra, Vincenzo
背景：评价新近发病的多发性硬化症患者、首次脱髓鞘事件(IDE)患者及与之匹配的复发-缓解型多发性硬化症(RRMS)患者黄斑及乳头周围的视网膜血管密度(Vd)。方法：应用光学相干断层血管成像(OCT-A)技术检测IDE、RRMS患者和正常对照组(HCS)浅、深毛细血管丛、脉络膜毛细血管丛和放射状毛细血管丛的VD。收集患者的临床病史，包括视神经炎病史、扩展残疾状态量表和病程。结果：30例患者(20例为IDE，10例为RRMS)和15例HCS患者入选。与对照组相比，ED组的放射状乳头周围毛细血管丛的VD值较低(Coeff.β=-3.578；p=0.002)。与HCS相比，RRMS患者的浅表毛细血管丛和放射状乳头周围毛细血管丛的VD值均较低(Coeff.β=-4.955；p=0.002，系数。贝塔=-7.446；p<；0.001)。此外，RRMS患者与IDE患者相比，RRMS患者的放射状乳头周围毛细血管丛中的Vd降低(Coeff.β=-3.868；p=0.003)。结论：OCT-A显示的乳头区血管密度降低可能是MS的早期事件，并可能作为疾病病理的生物标志物。
Background:To evaluate retinal vessel density (VD) in macular and in peripapillary regions in patients with recent onset of multiple sclerosis, at initial demyelinating event (IDE) and in matched relapsing-remitting multiple sclerosis (RRMS) patients. Methods:We evaluated VD in superficial capillary plexus, deep capillary plexus, choriocapillaris and radial peripapillary capillary plexus in IDE, RRMS patients and in matched healthy controls (HCs) through Optical Coherence Tomography Angiography (OCT-A). Clinical history, including history of optic neuritis, Expanded Disability Status scale and disease duration of patients were collected. Results:Thirty patients (20 with IDE and 10 with RRMS) and 15 HCs were enrolled. IDE patients showed a lower VD in radial peripapillary capillary plexus compared with controls (coeff. beta = -3.578;p= 0.002). RRMS patients displayed a lower VD in both superficial capillary plexus and radial peripapillary capillary plexus compared with HCs (coeff. beta = -4.955;p= 0.002, and coeff. beta = -7.446;p< 0.001, respectively). Furthermore, RRMS patients showed a decreased VD in radial peripapillary capillary plexus compared with IDE patients (coeff. beta = -3.868;p= 0.003). Conclusions:Peripapillary region vessel density reduction, revealed through OCT-A, might be considered as an early event in MS, and might be relevant as a biomarker of disease pathology.