Differential expression of Langerhans cells in the epidermis of patients with leprosy.
Differential expression of Langerhans cells in the epidermis of patients with leprosy.
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麻风病患者表皮朗格汉斯细胞的差异表达。
DOI：
10.1111/j.1365-2133.1989.tb01395.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Tausk,FA
中科院分区：
文献类型：
--
作者：
Gimenez,MF;Gigli,I;Tausk,FA
18例麻风性麻风（LL）患者的朗格汉斯细胞（LC）明显减少（P< 0.001），无论活检来自病变皮肤（398±186）还是健康皮肤（304±98）。细胞形态发生改变，主要表现为树突的缺失。24名对照组（年龄、性别和种族匹配）的LC平均数量为632±138。在结核患者（TT）中，根据活检部位的不同，观察到显著差异。9例受累皮肤活检的LC为993±206,11例健康皮肤活检的LC为448±96 （P< 0.001）。这种差异在另外6例交界性结核菌（BT）和TT患者中得到证实，这些患者同时从受累皮肤（973±179）和未受累皮肤（498±99）进行活检。在10例不确定麻风患者中，LC密度与对照人群（630±261）无差异。在BT和TT患者中LC数的表达可能代表这些细胞从健康皮肤迁移到受累区域或中心池的动员。在LL患者中发现的低密度可能会干扰分枝杆菌抗原的充分呈现，导致耐受性。或者，TT浸润中辅助性T细胞的存在可能产生招募LC的因子；它们在LL病变中的缺失可能是LC表达减少的原因。
Eighteen patients with lepromatous leprosy (LL) showed a significant reduction (P< 0.001) of Langerhans cells (LC) irrespective of whether the biopsies were obtained from involved (398±186) or healthy skin (304±98). The cells showed morphological changes consisting mainly of loss of dendritic processes. Twenty‐four controls (age, sex and race matched) had a mean number of LC of 632±138. In tuberculoid patients (TT) significant differences were observed, depending on the site of biopsy. Nine biopsies from involved skin had 993±206 LC, whereas 11 from healthy skin had 448±96 (P< 0.001). This difference was confirmed in six additional borderline tuberculoid (BT) and TT patients in whom biopsies were simultaneouslyy obtained from involved (973±179) and uninvolved skin (498±99). In 10 patients with indeterminate leprosy the LC density did not differ from the control population (630±261). The expression of LC numbers in BT and TT patients may represent migration of these cells from healthy skin to involved areas or mobilization of a central pool. The low density found in LL patients could interfere with adequate presentation of mycobacterial antigens leading to tolerance. Alternatively the presence of T helper cells in TT infiltrates may produce factors that recruit LC; their absence in LL lesions may account for the decrease in LC expression.