The clinical application of rhBMP-7 for the reconstruction of alveolar cleft
The clinical application of rhBMP-7 for the reconstruction of alveolar cleft
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DOI：
10.1016/j.bjps.2015.09.004
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发表时间：
2016-01-01
影响因子：
2.7
通讯作者：
Ray, Arup
中科院分区：
文献类型：
--
作者：
Ayoub, Ashraf;Roshan, Cherian P.;Ray, Arup
在这项研究中，通过放射学评估来了解应用重组人骨形态发生蛋白7（rhBMP-7）重建牙槽裂缺损的11例病例（9例单侧牙槽裂和2例双侧牙槽裂）后骨再生的有效性。通过在 I 型胶原蛋白载体上使用 3.5 mg rhBMP-7 (Osigraft OP1) 进行牙槽裂重建。术后 6 个月使用带有 Agfa Dentus M2 Comfort 咬合片的 Gendex 口腔内装置拍摄射线照片。骨填充量按照 Kindelan 四分制分级。患者平均随访6.6年。根据放射学分析，使用 Kindelan 量表，9 例单侧牙槽裂病例中有 8 例获得 I 级评分，1 例患者获得 II 级评分。在两个双侧牙槽裂中，仅一侧有骨形成。放射学外观显示与邻近骨相似的正常小梁模式。因此，rhBMP-7 在放射学和临床上成功地再生了牙槽裂处的骨，从而缩短了手术时间、没有供体部位发病并缩短了住院时间。这项初步研究的令人鼓舞的结果应该鼓励开展 II 期试验，以比较骨移植物与 BMP 重建牙槽缺损的效果。 (C) 2015 年英国整形、重建和美容外科医生协会。由爱思唯尔有限公司出版。保留所有权利。
In this study, radiographic assessment was performed to find out the effectiveness of bone regeneration following the application of recombinant human bone morphogenetic protein 7 (rhBMP-7) for the reconstruction of alveolar cleft defects in 11 cases: nine unilateral and two bilateral alveolar clefs. Reconstruction of the alveolar cleft was performed by using 3.5 mg of rhBMP-7 (Osigraft OP1) on a type I collagen carrier. Radiographs were taken 6 months post operation using a Gendex Intraoral Unit with Agfa Dentus M2 Comfort occlusal film. The amount of bony infill was graded on a Kindelan four-point scale. The patients were followed up for an average of 6.6 years. Based on the radiographic analysis, eight out of the nine unilateral alveolar cleft cases received a score of grade I and one patient had a grade II score, using the Kindelan scale. In the two bilateral alveolar clefts, only one side had bone formation. The radiographic appearance showed a normal trabecular pattern similar to the adjacent bone. Thus, rhBMP-7 was radiographically and clinically successful in regenerating the bone at the alveolar cleft which resulted in shortening of the operation time, absence of donor-site morbidity and a shorter hospital stay. The promising results of this preliminary study should encourage a phase II trial to compare bone grafts with BMP for the reconstruction of alveolar defects. (C) 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.