Exposure to sunlamps, tanning beds, and melanoma risk
Exposure to sunlamps, tanning beds, and melanoma risk
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DOI：
10.1007/s10552-008-9129-6
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发表时间：
2008-09-01
影响因子：
2.3
通讯作者：
Ernstoff, Marc S.
中科院分区：
文献类型：
--
作者：
Clough-Gorr, Kerri M.;Titus-Ernstoff, Linda;Ernstoff, Marc S.
目的评估日光灯和晒黑床设备使用对黑色素瘤风险的单独影响。方法对新罕布什尔州423例黑色素瘤患者和678例对照者进行基于人群的病例对照研究。暴露数据，包括日光灯和晒黑床的使用，通过电话采访收集。协会进行了评估，使用logistic回归analysis.Results约17%的参与者曾经使用过日光灯，和大多数使用（89%）发生在1980年之前。曾经使用日光灯的OR为1.39（95%CI 1.00-1.96），开始使用日光灯< 20年的OR为1.23（95%CI 0.81-1.88），开始使用日光灯≥ 20年的OR为1.71（95%CI 1.00-2.92）。数据表明，随着日光灯使用次数和使用时间的增加，风险增加（趋势检验p = 0.02）。晒黑床使用的总体流行率为22%，大多数使用（83%）发生在1980年之后。曾经使用晒黑床的OR为1.14（95%CI 0.80-1.61）;没有证据表明风险随使用频率或持续时间增加而增加。OR为1.96（95%CI 1.06-3.61）为已使用两个device.Conclusion结果表明，日光灯的使用和黑色素瘤的风险之间的适度关联，并增加风险与更大的频率和使用时间。没有发现与晒黑床的使用相关，但可能没有足够的滞后时间来评估潜在的影响。
Objective To estimate the separate effects of sunlamp and tanning bed device use on melanoma risk.Methods Population-based case-control study of 423 cases of melanoma and 678 controls in the state of New Hampshire. Exposure data, including sunlamp and tanning bed use, were collected by telephone interview. Associations were evaluated using logistic regression analyses.Results About 17% of participants ever used a sunlamp, and most use (89%) occurred before 1980. The OR was 1.39 (95% CI 1.00-1.96) for ever using a sunlamp, 1.23 (95% CI 0.81-1.88) for those starting sunlamp use < 20 years, and 1.71 (95% CI 1.00-2.92) for those starting >= 20 years. Data suggested increasing risk with number of sunlamp uses and with duration of use (tests of trend p = 0.02). The overall prevalence of tanning bed use was 22% and most use (83%) occurred after 1980. The OR was 1.14 (95% CI 0.80-1.61) for ever using a tanning bed; there was no evidence that risk increased with frequency or duration of use. The OR was 1.96 (95% CI 1.06-3.61) for having used both devices.Conclusion Results suggest a modest association between sunlamp use and melanoma risk, and increasing risk with greater frequency and duration of use. No association with tanning bed use was found, but sufficient lag time may not have elapsed to assess a potential effect.