State-dependent interhemispheric inhibition reveals individual differences in motor behavior in chronic stroke.
State-dependent interhemispheric inhibition reveals individual differences in motor behavior in chronic stroke.
复制标题
状态依赖性半球间抑制揭示了慢性中风运动行为的个体差异。
DOI：
10.1016/j.clinph.2023.02.177
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Borich,MichaelR
中科院分区：
文献类型：
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作者：
Mirdamadi,JasmineL;Xu,Jing;Arevalo-Alas,KarlaM;Kam,LianaK;Borich,MichaelR
目的研究慢性中风幸存者与神经典型老年人对照组相比的状态依赖性半球间抑制（IHI），并测试异常IHI调制是否与上肢运动行为相关。MethodsDualcoil transcranial magnetic stimulation（TMS）双向测量IHI，在两种活动状态下，在非损伤和损伤运动皮层（M1）之间：（1）在休息时和（2）在对侧等长手部肌肉收缩期间。通过在对侧M1上的测试刺激之前提供8毫秒或50毫秒的条件刺激来测试IHI。瘫痪运动行为进行了评估的临床措施的损害，力量，和灵巧，和镜像活动在non-parativebhand.ResultsStroke幸存者表现出减少IHI在休息，和较少的IHI调制（主动休息）相比，控制。IHI调制的个体差异与运动行为差异相关，其中较大的IHI调制与较大的运动障碍和更多的镜像相关。相反，有IHI在休息和运动behavior.ConclusionsAbnormal状态依赖的大脑半球间回路活动可能是更敏感的中风后运动功能障碍比在一个单一的motor state. Significance评估状态依赖的变化，神经回路可以提高模型中风恢复和通知康复干预。
ObjectiveTo investigate state-dependent interhemispheric inhibition (IHI) in chronic stroke survivors compared to neurotypical older adult controls, and test whether abnormal IHI modulation was associated with upper extremity motor behavior.MethodsDual-coil transcranial magnetic stimulation (TMS) measured IHI bi-directionally, between non-lesioned and lesioned motor cortex (M1) in two activity states: (1) at rest and (2) during contralateral isometric hand muscle contraction. IHI was tested by delivering a conditioning stimulus 8-msec or 50-msec prior to a test stimulus over contralateral M1. Paretic motor behavior was assessed by clinical measures of impairment, strength, and dexterity, and mirroring activity in the non-paretic hand.ResultsStroke survivors demonstrated reduced IHI at rest, and less IHI modulation (active – rest) compared to controls. Individual differences in IHI modulation were related to motor behavior differences where greater IHI modulation was associated with greater motor impairment and more mirroring. In contrast, there were no relationships between IHI at rest and motor behavior.ConclusionsAbnormal state-dependent interhemispheric circuit activity may be more sensitive to post-stroke motor deficits than when assessed in a single motor state.SignificanceCharacterizing state-dependent changes in neural circuitry may enhance models of stroke recovery and inform rehabilitation interventions.