Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins
Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins
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DOI：
10.1093/nar/27.1.260
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发表时间：
1999-01-01
影响因子：
14.9
通讯作者：
Sonnhammer, ELL
中科院分区：
文献类型：
--
作者：
Bateman, A;Birney, E;Sonnhammer, ELL
Pfam是蛋白质结构域家族的多重比对和轮廓隐马尔可夫模型的集合。3.1版是Pfam数据库的主要更新，包含1313个家族，可在欧洲的万维网http://www.sanger.ac.uk/Software/Pfam/和http：//www.cgr.ki.se/Pfam/以及美国的http://pfam.wustl.edu/上获得。SWISS-PROT-35和SP-TrEMBL-5中超过54%的蛋白质与Pfam家族匹配，自2.1版以来Pfam的主要变化是我们现在使用更先进的HMMER软件第2版，该软件更灵敏并提供匹配的期望值，并且现在包括来自SP-TrEMBL-5和SWISS-PROT的蛋白质。
Pfam is a collection of multiple alignments and profile hidden Markov models of protein domain families. Release 3.1 is a major update of the Pfam database and contains 1313 families which are available on the World Wide Web in Europe at http://www.sanger.ac.uk/Software/Pfam/ and http://www.cgr.ki.se/Pfam/, and in the US at http://pfam.wustl.edu/. Over 54% of proteins in SWISS-PROT-35 and SP-TrEMBL-5 match a Pfam family, The primary changes of Pfam since release 2.1 are that we now use the more advanced version 2 of the HMMER software, which is more sensitive and provides expectation values for matches, and that it now includes proteins from both SP-TrEMBL-5 and SWISS-PROT.