The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway.
The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway.
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DOI：
10.1016/j.celrep.2019.08.032
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发表时间：
2019-09
期刊：
影响因子：
8.8
通讯作者：
K. Kamimura;Ai Odajima;Yuko Ikegawa;Chikako Maru;N. Maeda
中科院分区：
文献类型：
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作者：
K. Kamimura;Ai Odajima;Yuko Ikegawa;Chikako Maru;N. Maeda
在缺乏食物的条件下，果蝇在神经肌肉接头(NMJ)的运动速度和突触数量增加。章鱼胺是去甲肾上腺素的无脊椎动物对应物，在这一过程中发挥着关键作用；然而，其潜在的机制仍不清楚。在这里，我们发现GluRIIA(GluRIIA)对I型突触的形成、突触后GluRIIA的表达和幼虫的运动速度具有负性调节作用。饥饿诱导的章鱼胺能信号降低DLP的表达，导致突触形成和运动的增加。DLP由突触后肌细胞表达，抑制由突触前BMP受体Wit和突触后含GluRIIA的离子型谷氨酸受体组成的非规范BMP途径。我们发现，在饥饿过程中，DLP的减少增加了非规范的BMP信号，导致GluRIIA的表达、I型Bouton数量和运动速度增加。我们的结果表明，章鱼胺通过调节DLP来控制饥饿诱导的神经可塑性，并为蛋白多糖如何影响行为和突触可塑性提供了见解。
Under food deprivation conditions,Drosophilalarvae exhibit increases in locomotor speed and synaptic bouton numbers at neuromuscular junctions (NMJs). Octopamine, the invertebrate counterpart of noradrenaline, plays critical roles in this process; however, the underlying mechanisms remain unclear. We show here that a glypican (Dlp) negatively regulates type I synaptic bouton formation, postsynaptic expression of GluRIIA, and larval locomotor speed. Starvation-induced octopaminergic signaling decreases Dlp expression, leading to increases in synapse formation and locomotion. Dlp is expressed by postsynaptic muscle cells and suppresses the non-canonical BMP pathway, which is composed of the presynaptic BMP receptor Wit and postsynaptic GluRIIA-containing ionotropic glutamate receptor. We find that during starvation, decreases in Dlp increase non-canonical BMP signaling, leading to increases in GluRIIA expression, type I bouton number, and locomotor speed. Our results demonstrate that octopamine controls starvation-induced neural plasticity by regulating Dlp and provides insights into how proteoglycans can influence behavioral and synaptic plasticity.