Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall
Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall
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DOI：
10.1016/j.carres.2012.02.028
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发表时间：
2012-07-01
影响因子：
3.1
通讯作者：
Barreto-Bergter, Eliana
中科院分区：
文献类型：
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作者：
Figueiredo, Rodrigo Tinoco;Bittencourt, Vera Carolina B.;Barreto-Bergter, Eliana
博伊地假杆菌是一种广泛存在于环境中的机会性真菌，最近在免疫功能低下和免疫功能正常的宿主中作为局部和播散性感染的媒介出现。宿主对真菌的反应部分依赖于进化保守受体的激活，包括toll样受体和吞噬受体。本文将对波氏假蝇细胞壁α -葡聚糖和鼠李甘露聚糖的分离、结构特征及其在诱导先天免疫应答中的作用进行综述。(C) 2012 Elsevier Ltd.版权所有。
Pseudallescheria boydii is an opportunistic fungus widespread in the environment, and has recently emerged as an agent of localized as well as disseminated infections in both immunocompromised and immunocompetent hosts. The host response to fungi is in part dependent on the activation of evolutionary conserved receptors including Toll-like receptors and phagocytic receptors. This review will discuss the isolation and structural characterization of alpha-glucans and rhamnomannans from P. boydii cell wall and their roles in the induction of innate immune response. (C) 2012 Elsevier Ltd. All rights reserved.