Brown adipose tissue: development, metabolism and beyond.
Brown adipose tissue: development, metabolism and beyond.
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DOI：
10.1042/bj20130457
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发表时间：
2013-07-15
期刊：
影响因子：
--
通讯作者：
Tseng YH
中科院分区：
文献类型：
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作者：
Schulz TJ;Tseng YH
肥胖是几种常见疾病的主要风险因素，包括2型糖尿病、血脂异常、非酒精性脂肪肝、心血管疾病，甚至一些癌症。虽然脂肪量增加是肥胖的主要特征，但并不是所有的脂肪库都是一样的。白色脂肪组织中的脂肪细胞含有单个大脂滴，在能量储存中起着众所周知的作用。相比之下，棕色脂肪组织专门用于产热能量消耗。由于棕色脂肪具有消耗能量和调节甘油三酯和葡萄糖代谢的重要能力，并且在成年人中也存在，因此棕色脂肪可能是治疗肥胖和代谢综合征的潜在靶点。毫无疑问，要使这种治疗成为可能，迫切需要关于棕色脂肪形成及其活性调控的基础知识。本文综述了近年来有关发育和激素信号调控棕色脂肪形成和活性及其代谢功能的研究进展。
Obesity represents a major risk factor for the development of several of our most common medical conditions, including type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver, cardiovascular disease, and even some cancers. While increased fat mass is the main feature of obesity, not all fat depots are created equal. Adipocytes found in white adipose tissue contain a single large lipid droplet and play well-known roles in energy storage. By contrast, brown adipose tissue is specialized for thermogenic energy expenditure. Due to its significant capacity to dissipate energy and regulate triglyceride and glucose metabolism and its demonstrated presence in adult humans, brown fat could be a potential target for the treatment of obesity and metabolic syndrome. Undoubtedly, fundamental knowledge about the formation of brown fat and regulation of it activity is imperatively needed to make such therapeutics possible. In this review, we integrate the recent advancements on the regulation of brown fat formation and activity by developmental and hormonal signals in relation to its metabolic function.