Transcranial direct current stimulation over somatosensory cortex decreases experimentally induced acute pain perception
Transcranial direct current stimulation over somatosensory cortex decreases experimentally induced acute pain perception
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DOI：
10.1097/ajp.0b013e318157233b
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Paulus, Walter
中科院分区：
文献类型：
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作者：
Antal, Andrea;Brepohl, Nadine;Paulus, Walter
目的：包括初级体感觉皮层在内的多个皮层区域被认为与伤害感觉有关。本研究旨在探讨经颅直流电刺激（tDCS）无痛无创调节体感觉皮层兴奋性对Tm:YAG激光诱导的急性痛觉的影响。方法：对10名健康受试者进行正极、正极和假性tDCS前后的主观疼痛评分和激光诱发电位N1、N2、P2分量振幅变化进行分析。结果：我们的研究结果表明，当tDCS一侧的对侧手受到激光刺激时，阴极tDCS显著降低了痛觉和N2分量的振幅，而阳极和假刺激条件没有显著影响。讨论：我们的研究强调了这种技术的抗伤害感受作用，并可能有助于理解疼痛缓解的机制。从药理学角度来看，该方法可以延长兴奋性降低的后效，适用于不同的慢性疼痛患者。
Objective: Multiple cortical areas including the primary somatosensory cortex are known to be involved in nociception. The aim of this study was to investigate the effect of transcranial direct current stimulation (tDCS) that modulates the cortical excitability painlessly and noninvasively, over somatosensory cortex on acute pain perception induced with a Tm:YAG laser.Methods: Subjective pain rating scores and amplitude changes of the N1, N2, and P2 components of laser-evoked potentials of 10 healthy participants were analyzed before and after anodal, cathodal, and sham tDCS.Results: Our results demonstrate that cathodal tDCS significantly diminished pain perception and the amplitude of the N2 component when the contralateral hand to the side of tDCS was laser-stimulated, whereas anodal and sham stimulation conditions had no significant effect.Discussion: Our study highlights the antinociceptive effect of this technique and may contribute to the understanding of the mechanisms underlying pain relief. The pharmacologic prolongation of the excitability-diminishing after-effects would render the method applicable to different patient populations with chronic pain.