Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women
Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women
复制标题
男性和女性的内皮功能障碍、血管结构异常和下尿路症状
DOI：
10.1016/j.ijcard.2018.02.041
复制
发表时间：
2018
影响因子：
3.5
通讯作者：
Kuwahara Yo
中科院分区：
文献类型：
--
作者：
Matsui Shogo;Kajikawa Masato;Maruhashi Tatsuya;Iwamoto Yumiko;Oda Nozomu;Kishimoto Shinji;Hashimoto Haruki;Hidaka Takayuki;Kihara Yasuki;Chayama Kazuaki;Hida Eisuke;Goto Chikara;Aibara Yoshiki;Nakashima Ayumu;Yusoff Farina Mohamad;Noma Kensuke;Kuwahara Yo
下尿路症状（LUTS）不仅是老年人常见的症状，而且是未来心血管事件的危险因素。方法以血流介导的血管舒张（FMD）和硝酸甘油诱导的血管舒张（NID）为血管功能，以臂踝脉搏波速度（baPWV）为血管结构，采用国际前列腺症状评分（IPSS）对287名男性和147名女性进行LUTS评分。FMD、NID和baPWV。中度至重度LUTS与男性冠心病患病率相关，但与女性无关。男性中重度LUTS组FMD和NID明显低于无轻度LUTS组（分别为2.1 ± 2.0%vs.4.0 ± 3.0%，9.3 ± 6.1%vs.12.8 ± 6.6%，P < 0.001）。中重度LUTS组baPWV明显高于无轻度LUTS组（1722 ± 386 cm/s vs. 1509 ± 309 cm/s，P< 0.001）。在多变量分析中，FMD与男性中重度LUTS的比值比降低独立相关（OR：0.83，95%CI，0.72-0.95;P= 0.008），但在女性中不相关。NID和baPWV没有独立与中度至重度LUTS无论是在男性或women.ConclusionsThese研究结果表明，内皮功能障碍与LUTS在男性。临床试验注册信息临床试验网址：http：//UMIN;临床试验注册号：UMIN 000003409。
BackgroundLower urinary tract symptoms (LUTS) is not only common symptoms in elderly men and women but also risk of future cardiovascular events. The purpose of this study was to evaluate the relationships of vascular function and structure with LUTS in men and women.MethodsWe investigated flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) as vascular function, brachial-ankle pulse wave velocity (baPWV) as vascular structure, and LUTS assessed by International Prostate Symptom Score (IPSS) in 287 men and 147 women.ResultsIPSS was significantly correlated with traditional cardiovascular risk factors, Framingham risk score, FMD, NID and baPWV. Moderate to severe LUTS was associated with the prevalence of coronary heart disease in men but not in women. In men, FMD and NID were significantly lower in the moderate to severe LUTS group than in the none to mild LUTS group (2.1 ± 2.0% vs. 4.0 ± 3.0% and 9.3 ± 6.1% vs. 12.8 ± 6.6%,P< 0.001, respectively). baPWV was significantly higher in the moderate to severe LUTS group than in the none to mild LUTS group (1722 ± 386 cm/s vs. 1509 ± 309 cm/s,P< 0.001). In multivariate analysis, FMD was independently associated with a decrease in the odds ratio of moderate to severe LUTS in men (OR: 0.83, 95% CI, 0.72–0.95;P= 0.008) but not in women. NID and baPWV were not independently associated with moderate to severe LUTS either in men or women.ConclusionsThese findings suggest that endothelial dysfunction is associated with LUTS in men. LUTS in men may be useful for a predictor of cardiovascular events.Clinical trial registration informationURL for Clinical Trial: http://UMIN; Registration Number for Clinical Trial: UMIN000003409.