Telomere length, cigarette smoking, and bladder cancer risk in men and women
Telomere length, cigarette smoking, and bladder cancer risk in men and women
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DOI：
10.1158/1055-9965.epi-06-0961
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发表时间：
2007-04-01
影响因子：
3.8
通讯作者：
De Vivo, Immaculata
中科院分区：
文献类型：
--
作者：
McGrath, Monica;Wong, Jason Y. Y.;De Vivo, Immaculata
截短的端粒是大多数癌症的定义特征之一。鉴于端粒在肿瘤发生中的作用，我们推断，先天性短端粒可能与膀胱癌风险增加有关。使用定量实时PCR，我们测量了膀胱癌病例和健康对照的相对端粒长度，并在嵌套在卫生专业人员随访研究中的病例对照研究和嵌套在护士健康研究中的病例对照研究中评估了端粒长度，吸烟和膀胱癌风险之间的关联。膀胱癌患者（n = 184）的端粒明显短于对照组（n = 192）。病例组平均相对端粒长度为0.23（SD，0.16），对照组为0.27（SD，0.15）（P = 0.001）。端粒最短的四分位数个体与端粒最长的四分位数个体相比，膀胱癌的调整优势比为1.88（95%置信区间，1.05，3.36）（P趋势= 0.006）。我们观察到男性和女性的端粒长度存在统计学显著差异（P < 0.001）;然而，性别、端粒长度和膀胱癌风险之间的相互作用并不显著。我们还观察到不同吸烟包年的端粒长度有显著差异（P = 0.01）。这些发现表明，截短的端粒与膀胱癌风险增加有关。
Truncated telomeres are among the defining characteristics of most carcinomas. Given the role of telomeres in tumorigenesis, we reasoned that constitutionally short telomeres might be associated with an increased risk of bladder cancer. Using quantitative real-time PCR, we measured relative telomere length in bladder cancer cases and healthy controls and evaluated the association between telomere length, cigarette smoking, and bladder cancer risk in a case-control study nested within the Health Professionals Follow-up Study and a case-control study nested within the Nurses' Health Study. Telomeres were significantly shorter in bladder cancer cases (n = 184) than in controls (n = 192). The mean relative telomere length in cases was 0.23 (SD, 0.16) versus 0.27 (SD, 0.15) in controls (P = 0.001). The adjusted odds ratio for bladder cancer was 1.88 (95% confidence interval, 1.05, 3.36) for individuals in the quartile with the shortest telomeres as compared with individuals in the quartile with the longest telomeres (P-trend = 0.006). We observed a statistically significant difference in telomere length among men and women (P < 0.001); however, the interaction between gender, telomere length, and bladder cancer risk was not significant. We also observed a significant difference in telomere length across categories of pack-years of smoking (P = 0.01). These findings suggest that truncated telomeres are associated with an increased risk of bladder cancer.