STRENUOUS PHYSICAL-ACTIVITY IN YOUNG ADULTHOOD AND RISK OF BREAST-CANCER (UNITED-STATES)
STRENUOUS PHYSICAL-ACTIVITY IN YOUNG ADULTHOOD AND RISK OF BREAST-CANCER (UNITED-STATES)
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DOI：
10.1007/bf00051410
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发表时间：
1995-07-01
影响因子：
2.3
通讯作者：
WILLETT, WC
中科院分区：
文献类型：
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作者：
MITTENDORF, R;LONGNECKER, MP;WILLETT, WC
关于剧烈体力活动与乳腺癌之间关系的流行病学数据有限且不一致。由于乳腺癌的风险可能受到卵巢功能的影响，而卵巢功能又受到身体活动的调节，因此运动可能与乳腺癌风险降低相关的假设值得进一步研究。因此，我们在1988 ~ 1991年进行了一项大型病例对照研究，访问了缅因州、马萨诸塞州、新罕布什尔州和威斯康星州（美国）的6,888名乳腺癌妇女（17 ~ 74岁）。被采访的对照组（9,539名女性，18至74岁）是从有执照的司机名单（年轻女性）或从医疗保险登记者名册（老年女性）中随机选择的。我们使用logistic回归模型的多变量调整优势比（OR）和95%置信区间（CI）来估计14至22岁时自我报告的体力活动与乳腺癌之间的相对风险。在14至22岁期间报告任何剧烈体力活动的女性患乳腺癌的风险适度降低（OR = 0.95，CI = 0.93-0.97）。然而，那些每天至少锻炼一次的人患乳腺癌的风险降低了50%（OR = 0.5，CI = 0.4-0.7）。这些数据支持这样的假设，即身体活跃的女性患乳腺癌的风险降低。
The epidemiologic data on the relation between strenuous physical activity and breast cancer are limited and inconsistent. Because risk of breast cancer may be influenced by ovarian function which, in turn, is modulated by physical activity, the hypothesis that exercise may be associated with a reduced risk of breast cancer merits further investigation. We, therefore, conducted a large case-control study in 1988-91, and interviewed 6,888 women (17 to 74 years of age) with breast cancer in Maine, Massachusetts, New Hampshire, and Wisconsin (United States). Interviewed controls (9,539 women, 18 to 74 years of age) were selected randomly from lists of licensed drivers (for younger women) or from a roster of Medicare enrollees (for older women). We used multivariate adjusted odds ratios (OR) and 95 percent confidence intervals (CI) from logistic regression models to estimate relative risks between self-reported physical activity when 14 to 22 years of age and breast cancer, When compared with sedentary controls, women who reported any strenuous physical activity during ages 14 to 22 years had a modest reduction in the risk of breast cancer (OR = 0.95, CI = 0.93-0.97). However, those who exercised vigorously at least once a day had a 50 percent reduction in risk of breast cancer (OR = 0.5, CI = 0.4-0.7). These data support the hypothesis that women who are physically active have a reduced risk of breast cancer.