LOCAL AND SYSTEMIC EFFECTS OF CIGARETTE-SMOKING ON FOLATE AND VITAMIN-B-12
LOCAL AND SYSTEMIC EFFECTS OF CIGARETTE-SMOKING ON FOLATE AND VITAMIN-B-12
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DOI：
10.1093/ajcn/60.4.559
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发表时间：
1994-10-01
影响因子：
7.1
通讯作者：
KRUMDIECK, CL
中科院分区：
文献类型：
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作者：
PIYATHILAKE, CJ;MACALUSO, M;KRUMDIECK, CL
在 39 名当前吸烟者 (CS) 和 60 名非当前吸烟者 (NCS) 中进行了一项横断面研究，以评估吸烟对循环系统和直接暴露于香烟烟雾的组织中叶酸和维生素 B-12 浓度的影响。单变量分析显示，与 NCS 相比，CS 中血浆、红细胞 (RBC) 和颊粘膜 (BM) 叶酸和 BM 维生素 B-12 浓度显着降低。控制其他变量后，吸烟与血浆、红细胞和骨髓细胞中叶酸和维生素 B-12 浓度之间的关联性降低。总叶酸摄入量和血浆维生素 C 浓度是血浆和红细胞叶酸浓度的重要预测因子。在抽取血样前 < 1 小时内最后一次吸烟的受试者中叶酸的血浆和红细胞浓度显着低于较早吸烟的受试者。在目前推荐的叶酸膳食摄入量 (RDA) 下，CS 的血浆叶酸浓度比 NCS 低 42%，而在摄入量为 RDA 的三倍时，CS 和 NCS 的血浆叶酸浓度相同。结果还表明，CS 的 BM 叶酸和维生素 B-12 浓度低于 NCS。
A cross-sectional study was carried out among 39 current smokers (CS) and 60 noncurrent smokers (NCS) to evaluate the effects of cigarette smoking on folate and vitamin B-12 concentrations in the circulation and in tissues directly ex posed to cigarette smoke. Univariate analysis showed significantly lower plasma, red blood cell (RBC), and buccal mucosa (BM) folate and BM vitamin B-12 concentrations in CS compared with NCS. The association between smoking and folate and vitamin B-12 concentrations in plasma, RBCs, and BM cells was reduced after other variables were controlled for. Total folate intake and plasma vitamin C concentrations were significant predictors of plasma and RBC folate concentrations. The plasma and RBC concentrations of folate were significantly lower in subjects who had last smoked < 1 h before the blood sample was drawn than in subjects who had smoked earlier. At the current recommended dietary allowance (RDA) for folate, CS had 42% lower plasma folate concentrations than NCS, whereas at an intake three times the RDA, the plasma folate concentration was the same for CS and NCS. The results also suggested that CS have BM folate and vitamin B-12 concentrations that are lower than those of NCS.