Ibuprofen or acetaminophen for the acute treatment of migraine in children: A double-blind, randomized, placebo-controlled, crossover study
Ibuprofen or acetaminophen for the acute treatment of migraine in children: A double-blind, randomized, placebo-controlled, crossover study
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DOI：
10.1212/wnl.48.1.103
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发表时间：
1997-01-01
期刊：
影响因子：
9.9
通讯作者：
Santavuori, P
中科院分区：
文献类型：
--
作者：
Hamalainen, ML;Hoppu, K;Santavuori, P
儿童偏头痛急性治疗药物的疗效迄今尚未在对照试验中进行过研究。我们进行了一项研究，以评估对乙酰氨基酚和布洛芬的疗效。88名儿童，年龄4.0至15.8岁，偏头痛参加了一项双盲交叉研究。每名儿童的三次发作以随机顺序在家中单次口服15 mg/kg对乙酰氨基酚，10 mg/kg布洛芬和安慰剂。主要终点是2小时后重度或中度头痛（1 - 5级中大于或等于3级）减少至少两个等级，对乙酰氨基酚组达到该终点的次数是安慰剂组的两倍，布洛芬组是安慰剂组的三倍。在2小时内终止偏头痛的可能性是对乙酰氨基酚的两倍。在意向治疗分析中，服用布洛芬和对乙酰氨基酚的儿童的改善率是服用安慰剂的两倍。布洛芬和对乙酰氨基酚都是治疗儿童重度或中度偏头痛发作的有效和经济的治疗方法。我给了最好的救济。
Efficacy of drugs for the acute treatment of migraine in children has not so far been studied in well controlled trials. We conducted a study to evaluate the efficacy of acetaminophen and ibuprofen. Eighty-eight children, aged 4.0 to 15.8 years, with migraine participated in a double-blind crossover study. Three attacks per child were treated in random order with single oral doses of 15 mg/kg acetaminophen, 10 mg/kg ibuprofen, and placebo at home. The primary end point, reduction in severe or moderate headache (grade greater than or equal to 3 on a scale of 1 to 5) by at least two grades after 2 hours, was reached twice as often with acetaminophen and three times as often with ibuprofen as with placebo. Ibuprofen was twice as likely as acetaminophen to abort migraine within 2 hours. In the intent-to-treat analysis, children improved twice as often with ibuprofen and acetaminophen as with placebo. Both ibuprofen and acetaminophen are effective and economical treatments for severe or moderate migraine attacks in children. Ibuprofen gave the best relief.