Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress.
Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress.
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DOI：
10.1016/j.dib.2015.12.025
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发表时间：
2016-03
期刊：
影响因子：
1.2
通讯作者：
Khurana S
中科院分区：
文献类型：
--
作者：
Jadeja RN;Urrunaga NH;Ahmad D;Khurana S
我们最近证明了M1毒蕈碱受体（M1R）在调节肝脏和肝细胞中的氧化应激中的作用（Urrunaga等人，2015）。在此，我们提供了关于新型M1R激动剂VU0357017（Lebois等人，2010），对H2O2介导的肝细胞损伤的影响，M1R拮抗剂VU0255035（Sheffler等人，2009）对体外H2O2处理肝细胞中过氧化氢酶和超氧化物歧化酶（SOD）活性的影响，以及最后，M1R消融对对乙酰氨基酚（APAP）处理小鼠中肝脏过氧化氢酶活性的影响。
We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015). Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010), on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) on catalase and super oxide dismutase (SOD) activities in H2O2–treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.