Endemic infection reduces transmission potential of an epidemic parasite during co-infection
Endemic infection reduces transmission potential of an epidemic parasite during co-infection
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地方性感染降低了共同感染期间流行性寄生虫的传播潜力
DOI：
10.1098/rspb.2013.1500
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Joanne Lello
中科院分区：
文献类型：
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作者：
Joanna Randall;Joanna Randall;Joanne Cable;I. Guschina;John L. Harwood;Joanne Lello
地方性、低毒力的寄生虫感染在自然界中很常见。这种感染可能会耗尽宿主资源，这反过来又可能影响其他寄生虫在共感染期间的繁殖。我们的目的是确定流行病寄生虫的繁殖和传播潜力是否受到地方性感染对宿主施加的能量成本的限制。测定了德国小蠊（Blattella germanica）随意喂食、饥饿和感染德国小蠊（Gregarina blattarum）的总脂质、三酰甘油（TAG）和极性脂质。然后，通过计算从这三个宿主群体出现的感染阶段的数量，评估了一种流行寄生虫——豆荚斯坦纳马（steinerma carpocapsae）的生殖产量。我们发现饥饿和格林林感染都降低了蟑螂的脂质，主要是通过消耗TAG。此外，饥饿和blattarum感染都减少了线虫传播阶段的出现。据我们所知，这是第一个直接证明由地方性感染引起的宿主资源枯竭可能影响流行病传播的研究。鉴于地方性感染在自然界中无处不在，今后对流行病传播的研究应更多地考虑地方性共同感染。
Endemic, low-virulence parasitic infections are common in nature. Such infections may deplete host resources, which in turn could affect the reproduction of other parasites during co-infection. We aimed to determine whether the reproduction, and therefore transmission potential, of an epidemic parasite was limited by energy costs imposed on the host by an endemic infection. Total lipids, triacylglycerols (TAG) and polar lipids were measured in cockroaches (Blattella germanica) that were fed ad libitum, starved or infected with an endemic parasite, Gregarina blattarum. Reproductive output of an epidemic parasite, Steinernema carpocapsae, was then assessed by counting the number of infective stages emerging from these three host groups. We found both starvation and gregarine infection reduced cockroach lipids, mainly through depletion of TAG. Further, both starvation and G. blattarum infection resulted in reduced emergence of nematode transmission stages. This is, to our knowledge, the first study to demonstrate directly that host resource depletion caused by endemic infection could affect epidemic disease transmission. In view of the ubiquity of endemic infections in nature, future studies of epidemic transmission should take greater account of endemic co-infections.