Genetic analysis of norovirus GII.4 variants circulating in Korea in 2008
Genetic analysis of norovirus GII.4 variants circulating in Korea in 2008
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DOI：
10.1007/s00705-010-0627-y
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Cheon, D. S.
中科院分区：
文献类型：
--
作者：
Park, K. S.;Jeong, H. S.;Cheon, D. S.
诺如病毒是引起传染性胃肠炎和食源性疾病暴发的最常见肠道病原体。特别是GII.4诺如病毒，是大多数流行病的罪魁祸首。在这里，我们提出的诺如病毒基因型在忠南，韩国，在2008年的分布数据，测量GII.4株之间的遗传变异，并比较韩国GII.4变种与参考株的基础上的237 bp的连接的ORF 1和ORF 2。我们检测到139个不同的菌株，形成了两个不同的基因簇具有显着的序列多样性。一个韩国星团（2008-Korea_a）与2006年在日本和欧洲出现的Sakai星团具有很高的相似性。另一个聚类（2008-Korea_B）是独特的，与以前报道的聚类无关。基因型GII.4被确认为韩国诺如病毒流行的主要原因。另一方面，食源性诺如病毒感染通常是由新出现的GII.4遗传变异引起的，与导致全球流行病的变异相似。
Noroviruses are the enteric pathogens most commonly responsible for infectious gastroenteritis and outbreaks of foodborne illness. The GII.4 norovirus, in particular, is responsible for the majority of epidemics. Here, we present data on the distribution of norovirus genotypes in Chungnam, Korea, in 2008, measure genetic variation among GII.4 strains, and compare Korean GII.4 variants with reference strains based on the 237-bp junction of ORF1 and ORF2. We detected 139 different strains, which formed two distinct genetic clusters with significant sequence diversity. One Korean cluster (2008-Korea_a) showed high similarity to the Sakai cluster that appeared in Japan and Europe in 2006. The other cluster (2008-Korea_b) was unique and unrelated to previously reported clusters. Genotype GII.4 was confirmed as the predominant cause of norovirus epidemics in Korea. Foodborne norovirus infections, on the other hand, were generally caused by emerging GII.4 genetic variants similar to those responsible for global epidemics.