GENETIC-LINKAGE MAP OF HUMAN CHROMOSOME-7 WITH 63 DNA MARKERS
GENETIC-LINKAGE MAP OF HUMAN CHROMOSOME-7 WITH 63 DNA MARKERS
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DOI：
10.1073/pnas.84.22.8006
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发表时间：
1987-11-01
影响因子：
11.1
通讯作者：
DONISKELLER, H
中科院分区：
文献类型：
--
作者：
BARKER, D;GREEN, P;DONISKELLER, H
人类染色体的高密度遗传图谱将允许疾病相关基因的准确定位，并提供在构建物理图谱时有用的路标。利用23个三代家系的分离数据和新近发展起来的多位点连锁分析技术，构建了一张包含63个多态性DNA标记的7号染色体遗传图谱。这张地图的跨度为女性250厘摩，男性170厘摩，其中大部分差异集中在几个区间内。标记的密度和信息量使得检测到与该染色体上的任何疾病基因的连锁的可能性很高，其中20个阶段已知的减数分裂是可用的。
High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed multilocus linkage-analysis technique. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.