Effects of glucocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain.
Effects of glucocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain.
复制标题
DOI：
10.1016/j.ejphar.2005.09.045
复制
发表时间：
2005-11
影响因子：
5
通讯作者：
I. Takasaki;T. Kurihara;H. Saegusa;S. Zong;T. Tanabe
中科院分区：
文献类型：
--
作者：
I. Takasaki;T. Kurihara;H. Saegusa;S. Zong;T. Tanabe
小鼠脊神经损伤诱导机械性异常性疼痛和热痛觉过敏。在损伤的脊髓中，糖皮质激素受体mRNA的表达增加，而在N型钙通道缺陷小鼠中，糖皮质激素受体mRNA的表达减少，其中神经病理性疼痛被消除。鞘内和腹腔注射糖皮质激素受体拮抗剂RU 486产生抗伤害性作用，而侧脑室注射没有效果。更具选择性的拮抗剂地塞米松21-甲磺酸抑制机械异常性疼痛和热痛觉过敏。这些结果表明，脊髓糖皮质激素受体在神经病理性疼痛中起重要作用，并且控制糖皮质激素受体的活性可能在神经病理性疼痛的治疗中具有重要意义。
Injury to the spinal nerves of mice induces mechanical allodynia and thermal hyperalgesia. In the injured spinal cord, the expression of glucocorticoid receptor mRNA was increased, whereas it was decreased in N-type Ca2+-channel-deficient mice, in which neuropathic pain is eliminated. Intrathecal and intraperitoneal injection of the glucocorticoid receptor antagonist RU486 produced antinociceptive effects, whereas intracerebroventricular injection was without effect. The more selective antagonist dexamethasone 21-mesylate suppressed both mechanical allodynia and thermal hyperalgesia. These results suggest that spinal glucocorticoid receptors play an important role in neuropathic pain, and that controlling the activity of glucocorticoid receptors may be of great importance in the treatment of neuropathic pain.