Electrophysiological mapping of the cochlear nucleus with multi-channel bipolar surface microelectrodes.
Electrophysiological mapping of the cochlear nucleus with multi-channel bipolar surface microelectrodes.
复制标题
使用多通道双极表面微电极对耳蜗核进行电生理测绘。
DOI：
10.1007/s00405-012-2077-5
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Oda K
中科院分区：
文献类型：
--
作者：
Wada H;Kumano S;Murakoshi M;Koyama S;Oda K
用两种电极间距为100和200 μm的多通道表面微电极记录豚鼠耳蜗核电刺激时的听觉电位。一致地观察到电诱发听觉脑干反应（EABR）的明确波，其振幅随刺激电流的增加而增加。使用这些多通道电极的电生理标测可以清楚地区分显示阳性EABR的刺激点和显示不可检测EABR的点，表明多通道表面微电极在临床应用中具有很大的潜力，可以确定听觉脑干植入物定位的最佳位置，并且可以更精确地区分音高。在应用于人类耳蜗核的生理标测之前，需要进一步研究以澄清人类的最佳电极间距离。
Auditory potentials in response to electrical stimulation of the cochlear nucleus were recorded in guinea pigs using two types of multi-channel surface microelectrodes with inter-electrode distance of 100 and 200 μm. Unequivocal waves of electrically evoked auditory brainstem responses (EABRs), which increased in amplitude with increasing stimulation current, were consistently observed. Electrophysiological mapping with these multichannel electrodes could clearly distinguish stimulation points showing positive EABRs from points showing undetectable EABRs, indicating that multi-channel surface microelectrodes have great potential in clinical use to determine the optimal location for the positioning of auditory brainstem implants, and may allow more precise discrimination of pitch. Further study to clarify the optimal inter-electrode distance for humans is necessary before application to physiological mapping in the human cochlear nucleus.