BIOLOGICAL-ACTIVITY OF STAPHYLOCOCCIN 462 - BACTERIOCIN FROM STAPHYLOCOCCUS-AUREUS
BIOLOGICAL-ACTIVITY OF STAPHYLOCOCCIN 462 - BACTERIOCIN FROM STAPHYLOCOCCUS-AUREUS
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DOI：
10.1128/aac.7.1.74
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发表时间：
1975-01-01
影响因子：
4.9
通讯作者：
HINSDILL, RD
中科院分区：
文献类型：
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作者：
HALE, EM;HINSDILL, RD
Staphylococcin 462是一种由金黄色葡萄球菌菌株462产生的蛋白抑制剂。在肉汤培养中，易受影响。金黄色葡萄球菌140和19对细菌素治疗的反应是停止生长和细胞分裂。通过测量放射性前体的掺入对大分子合成的检查揭示了这一点。金黄色葡萄球菌140立即停止合成蛋白质。暴露于葡萄球菌462后，脱氧核糖核酸和核糖核酸的合成也很快受到抑制，但不完全。ofS治疗。含有该抑制剂的Aureus140使细胞腺苷5 ' -三磷酸水平迅速下降至对照水平的60%左右。70株革兰氏阳性菌对葡萄球菌462敏感，7属24株（34%）敏感。
Staphylococcin 462 is a proteinaceous inhibitor produced byStaphylococcus aureusstrain 462. In broth cultures, susceptibleS. aureusstrain 140 and 19 respond to treatment with the bacteriocin by stopping growth and cell division. Examination of macromolecular synthesis by measuring the incorporation of radioactive precursors revealed thatS. aureus140 stops synthesizing protein immediately. After exposure to staphylococcin 462, the synthesis of deoxyribonucleic acid and ribonucleic acid is quickly inhibited also, but not as completely. Treatment ofS. aureus140 with the inhibitor causes a rapid drop in cellular adenosine 5′-triphosphate level to about 60% of control levels. Of the 70 strains of gram-positive bacteria tested for susceptibility to staphylococcin 462, 24 (34%), distributed among 7 genera, were susceptible.