Prognostic relevance of micro-vessel density in cancer of the urinary bladder.
Prognostic relevance of micro-vessel density in cancer of the urinary bladder.
复制标题
膀胱癌微血管密度的预后相关性。
作者：
R. Chaudhary;M. Bromley;Noel W. Clarke;C. Betts;R. Barnard;W. Ryder;S. Kumar
血管生成是肿瘤生长和转移的重要因素。已发现血管生成程度（微血管密度-MVD）与许多不同恶性肿瘤的肿瘤进展和疾病结果相关。我们研究了 88 名因移行细胞膀胱癌接受膀胱切除术的患者，以确定血管生成是否与癌症特异性生存相关。通过内皮细胞的 CD31 免疫染色来鉴定微血管。使用低放大倍数选择血管生成的活跃区域（“热点”）。使用 Chalkley 点标线进行血管计数。 3次计数的平均值用于统计分析。中位数计数为 3.4。单变量分析显示较高的 MVD 与预后恶化相关 (p = 0.02)。根据临床分期进行调整后，MVD 继续预测预后恶化 (p = 0.02)。 MVD 不受年龄、性别或既往放射治疗的影响。 MVD 与盆腔复发后患者死亡的风险相关（p = 0.03），并且手术时出现淋巴结转移的患者的 MVD 显着较高。总之，微血管密度被证明是膀胱移行细胞癌的独立预后标志物。
Angiogenesis is an important factor in tumour growth and metastasis. Degree of angiogenesis (microvascular density-MVD) has been found to correlate with tumour progression and disease outcome in a number of different malignancies. We studied 88 patients undergoing cystectomy for transitional cell bladder cancer to determine if angiogenesis was associated with cancer specific survival. Microvessels were identified by immunostaining of endothelial cells for CD31. Active areas of angiogenesis ("hot spots") were selected using low magnification. The vessel count was performed using a Chalkley point graticule. The mean of 3 counts was used for statistical analysis. The median count was 3.4. Univariate analysis revealed that higher MVD was associated with worsening prognosis (p = 0.02). When adjusted for clinical stage MVD continued to predict worsening prognosis (p = 0.02). MVD was not affected by age or sex or by previous radiotherapy. MVD was associated with the risk of patients dying following pelvic recurrence (p = 0.03) and MVD was significantly higher in patients with lymph node metastasis at surgery. In conclusion, microvessel density proved to be an independent prognostic marker in transitional cell carcinoma of bladder.