Personality Influences the Reporting of Side Effects of Inhaled Corticosteroids in Asthma Patients
Personality Influences the Reporting of Side Effects of Inhaled Corticosteroids in Asthma Patients
复制标题
DOI：
10.1080/02770900802127022
复制
发表时间：
2008-01-01
影响因子：
1.9
通讯作者：
van Sonderen, Eric
中科院分区：
文献类型：
--
作者：
Foster, Juliet M.;Sanderman, Robbert;van Sonderen, Eric
理由。消极情感是与症状报告增加相关的焦虑的量度。在真实的生活中，很少有研究探讨药物引起的慢性病患者症状与药物相关性。目标.在这项横断面研究中，我们研究了哮喘患者吸入皮质类固醇的负性情感和自我报告的副作用之间的关系。我们还研究了由于副作用类型（主观与可观察到的副作用）和治疗影响（即，分级给药）。方法.共有228名哮喘患者接受吸入性皮质类固醇治疗，完成了测量吸入性皮质类固醇诱导的副作用（吸入性皮质类固醇问卷评分：0 =无; 100 =最差）和负面影响（正面和负面影响量表评分：10-50）的量表。根据公布的标准，患者被分为低，平均和高负情感组。结果负性情感高的患者报告的副作用（中位数评分20.5（IQR：11.4-33.0））显著高于负性情感低的患者组（负性情感低：7.1（3.1-15.6）;平均值：13.3（4.9-23.3））（p < 0.001）。低剂量组（r = 0.40-0.45）的不良反应与副作用的相关性强于中、高剂量组（r = 0.16-0.28）。结论.使用吸入性糖皮质激素的负性情绪较高的哮喘患者报告药物诱导的症状增加。临床医生应该意识到，除了吸入皮质类固醇剂量外，患者的个性也是报告药物相关副作用的重要因素。
Rationale. Negative affectivity is a measure of anxiety associated with increased reporting of symptoms. Few studies have explored this association with respect to drug-induced symptoms in patients taking medication for a chronic disease in real life. Objectives. In this cross-sectional study we examined the relationship between negative affectivity and self-reported side effects of inhaled corticosteroids in patients with asthma. We also investigated differential associations due to side effect type (subjective versus observable side effects) and treatment impact (i.e., hierarchical dosing). Methods. A total of 228 asthma patients, taking inhaled corticosteroids, completed scales measuring inhaled corticosteroid-induced side effects (Inhaled Corticosteroid Questionnaire scored: 0 = none; 100 = worst) and negative affectivity (Positive and Negative Affect Schedule scored: 10-50). Patients were grouped into low, average, and high negative affectivity groups based on published norms. Results. Patients high in negative affectivity reported significantly greater (p < 0.001) side effects (median score 20.5 (IQR: 11.4-33.0) than the groups of patients scoring lower on this measure (low negative affectivity: 7.1 (3.1-15.6); average: 13.3 (4.9-23.3)). The relationship between negative affectivity and side effects was stronger among patients taking low (r = 0.40-0.45) rather than mid to high inhaled corticosteroid doses (r = 0.16-0.28). Conclusions. Asthma patients with higher negative affectivity using inhaled corticosteroids report increased medication-induced symptoms. Clinicians should be aware that aside from inhaled corticosteroid dosage, the personality of the patient is an important factor in the reporting of drug-related side effects.