Control of Drosophila adult pattern by extradenticle.
Control of Drosophila adult pattern by extradenticle.
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发表时间：
1995
期刊：
影响因子：
4.6
通讯作者：
S. González-Crespo;G. Morata
中科院分区：
文献类型：
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作者：
S. González-Crespo;G. Morata
同源异型盒基因extradenticle（exd）作为同源异型基因的辅助因子在胚胎发育过程中的幼虫模式的规范。为了研究它在成年模式中的作用，我们已经产生了突变exd-细胞的克隆，并检查了它们对不同身体部位的影响。在某些区域，exd-克隆表现出与已知同源异型突变如超双胸（Ubx）、唇（lab）、无刺马兜铃足（ssa）或刺足（Antp）产生的同源异型转化相似的同源异型转化。在其他区域，exd的缺乏导致新的同源异型转化，产生异位的眼睛和腿。此外，exd也需要通常与同源异型结合无关的功能，如背腹图案的维持，成年附属物中的子图案的规格或中背层和生殖器中刚毛的排列。我们的研究结果表明，exd是至关重要的成人形态发生，不仅在同源异型功能，但也在其他几个发展过程。
The homeobox gene extradenticle (exd) acts as a cofactor of the homeotic genes in the specification of larval patterns during embryogenesis. To study its role in adult patterns, we have generated clones of mutant exd- cells and examined their effect on the different body parts. In some regions, exd- clones exhibit homeotic transformations similar to those produced by known homeotic mutations such as Ultrabithorax (Ubx), labial (lab), spineless-aristapedia (ssa) or Antennapedia (Antp). In other regions, the lack of exd causes novel homeotic transformations producing ectopic eyes and legs. Moreover, exd is also required for functions normally not associated with homeosis, such as the maintenance of the dorsoventral pattern, the specification of subpatterns in adult appendages or the arrangement of bristles in the mesonotum and genitalia. Our findings indicate that exd is critically involved in adult morphogenesis, not only in the homeotic function but also in several other developmental processes.