Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women.
Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women.
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DOI：
10.1016/j.envint.2016.12.021
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发表时间：
2017-03
影响因子：
11.8
通讯作者：
Kesner JS
中科院分区：
文献类型：
--
作者：
Luderer U;Christensen F;Johnson WO;She J;Ip HS;Zhou J;Alvaran J;Krieg EF Jr;Kesner JS
基本上，所有女性都暴露在多环芳烃(PAHs)中，这些多环芳烃是由化石燃料、木材、食品和烟草等有机材料不完全燃烧形成的。多环芳烃是啮齿类动物的卵巢毒物，吸烟与女性生殖异常有关。尿中羟化多环芳烃(OH-PAH)代谢产物的生物监测提供了一种通过多种途径暴露于PAHs的综合测量方法，并已被用于表征人类对PAHs的暴露。我们假设尿中的羟基多环芳烃浓度与女性的生殖功能有关。我们招募了居住在加利福尼亚州奥兰治县的18-44岁的女性，使用微型电子生育监测器对多个月经周期每天测量尿液黄体生成素(LH)和雌酮3-葡萄糖醛酸苷(E13G)；这些数据被用来计算内分泌终点。参与者还收集了周期第10天的尿样，用于测量9种OH-PAHs。使用贝叶斯混合建模方法构建了八个端点的模型，该方法具有特定于受试者的随机效果，允许每个参与者作为她的一组测量的基线。我们观察了个体OH-PAH浓度与卵泡期长度、卵泡期黄体生成素和E13G浓度、排卵前黄体生成素峰浓度以及排卵期E13G斜率和浓度之间的关系。我们已经证明了使用通过生育监测仪获得的尿生殖激素数据来计算内分泌终点的可行性，用于多个月经周期的卵巢功能的流行病学研究。结果表明，环境暴露于多环芳烃与女性卵巢功能的内分泌标记物的变化以多环芳烃特有的方式相关。
Essentially all women are exposed to polycyclic aromatic hydrocarbons (PAHs), formed during incomplete combustion of organic materials, including fossil fuels, wood, foods, and tobacco. PAHs are ovarian toxicants in rodents, and cigarette smoking is associated with reproductive abnormalities in women. Biomonitoring of hydroxylated PAH (OH-PAH) metabolites in urine provides an integrated measure of exposure to PAHs via multiple routes and has been used to characterize exposure to PAHs in humans. We hypothesized that concentrations of OH-PAHs in urine are associated with reproductive function in women. We recruited women 18–44 years old, living in Orange County, California to conduct daily measurement of urinary luteinizing hormone (LH) and estrone 3-glucuronide (E13G) using a microelectronic fertility monitor for multiple menstrual cycles; these data were used to calculate endocrine endpoints. Participants also collected urine samples on cycle day 10 for measurement of nine OH-PAHs. Models were constructed for eight endpoints using a Bayesian mixed modeling approach with subject-specific random effects allowing each participant to act as a baseline for her set of measurements. We observed associations between individual OH-PAH concentrations and follicular phase length, follicular phase LH and E13G concentrations, preovulatory LH surge concentrations, and periovulatory E13G slope and concentration. We have demonstrated the feasibility of using urinary reproductive hormone data obtained via fertility monitors to calculate endocrine endpoints for epidemiological studies of ovarian function during multiple menstrual cycles. The results show that environmental exposure to PAHs is associated with changes in endocrine markers of ovarian function in women in a PAH-specific manner.