Modeling immunotherapy of the tumor-immune interaction
Modeling immunotherapy of the tumor-immune interaction
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DOI：
10.1007/s002850050127
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发表时间：
1998-09-01
影响因子：
1.9
通讯作者：
Panetta, JC
中科院分区：
文献类型：
--
作者：
Kirschner, D;Panetta, JC
大量证据表明，使用细胞因子白细胞介素-2（IL-2）的免疫疗法可能会增强免疫系统对抗肿瘤。CD 4（+）T细胞是协调免疫应答的细胞，使用这些细胞因子作为免疫应答刺激以及淋巴细胞刺激、生长和分化的信号传导机制。由于肿瘤细胞开始是“自我”的，免疫系统可能无法有效地消除它们。免疫细胞疗法可以潜在地恢复或增强这些效果。我们通过数学建模来说明肿瘤细胞，免疫效应细胞和IL-2之间的动力学。这些努力能够解释肿瘤大小的短期肿瘤振荡以及长期肿瘤复发。然后，我们探讨了过继细胞免疫治疗对模型的影响，并描述了在什么情况下可以消除肿瘤。
A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2) may boost the immune system to fight tumors. CD4(+) T cells, the cells that orchestrate the immune response, use these cytokines as signaling mechanisms for immune-response stimulation as well as lymphocyte stimulation, growth, and differentiation. Because tumor cells begin as 'self', the immune system may not respond in an effective way to eradicate them. Adoptive cellular immunotherapy, can potentially restore or enhance these effects. We illustrate through mathematical modeling the dynamics between tumor cells, immune-effector cells, and IL-2. These efforts are able to explain both short tumor oscillations in tumor sizes as well as long-term tumor relapse. We then explore the effects of adoptive cellular immunotherapy on the model and describe under what circumstances the tumor can be eliminated.