Modulated microRNA expression during adult lifespan in Caenorhabditis elegans
Modulated microRNA expression during adult lifespan in Caenorhabditis elegans
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DOI：
10.1111/j.1474-9726.2006.00210.x
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发表时间：
2006-06-01
期刊：
影响因子：
7.8
通讯作者：
Driscoll, Monica
中科院分区：
文献类型：
--
作者：
Ibanez-Ventoso, Carolina;Yang, Maocheng;Driscoll, Monica
microrna （mirna）是一种小而丰富的转录物，可以结合部分同源的目标信息，从而抑制其在动物细胞中的翻译。mirna已被证明影响广泛的生物活动，包括发育命运决定、细胞信号传导和肿瘤发生。然而，我们对miRNA对衰老的影响知之甚少。我们检测了114个已鉴定的秀丽隐杆线虫mirna在成年期的表达，发现34个mirna在成年期表现出表达变化(P
MicroRNAs (miRNAs) are small, abundant transcripts that can bind partially homologous target messages to inhibit their translation in animal cells. miRNAs have been shown to affect a broad spectrum of biological activities, including developmental fate determination, cell signaling and oncogenesis. Little is known, however, of miRNA contributions to aging. We examined the expression of 114 identified Caenorhabditis elegans miRNAs during the adult lifespan and find that 34 miRNAs exhibit changes in expression during adulthood (P